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SPI Supplies Division
Structure Probe, Inc.

P.O. Box 656 West Chester, PA 19381-0656 USA
Phone: 1-(610)-436-5400 Fax: 1-(610)-436-5755
E-mail: spi3spi@2spi.com

WWW: http://www.2spi.com
Manufacturer's CAGE: 1P573

Material Safety Data Sheet

SPI #02846-AB and 02846A-AB Paraplast® Plus Tissue Embedding Medium


Section 1: Identification


Section 1: Identification of Product

Date Effective............. March 30, 2006
                            (most recent revision)


Chemical Name/Synonyms..... None known

Product Use..............  Tissue embedding medium

Chemical family..........  Hydrocarbon wax



Emergencies                
Contacting CHEMTREC:

24 Hour Emergency Use Only #'s......    
   Worldwide phone: 1-(703)-527-3887 
   Worldwide FAX:   1-(703)-741-6090  
   Toll-free phone: 1-(800)-424-9300 USA only


Product or Trade Name...... ParaplastŪ

CAS #...................... Mixture

Chemical Formula........... Not known

This MSDS has been compiled in accordance with EC Directive 91/155/EC and
OSHA's Hazcom Standard (29 CFR 1910.1200).



Section 2 Composition / Information on Ingredients


INGREDIENT NAME        CAS NUMBER/Codes   WEIGHT %    R Phrases    
Classification
Polyisobutylene          9003-27-4          < 1 %      R-None        None
                         204-066-3
Paraffin                 9002-74-2          > 98%      R-None        None
                         232-315-6
Dimethylsulfoxide        67-68-5            < 1%      R36/37/38       Xi
                         200-664-3




Section 3: Hazards Identification


Emergency overview:

Main hazards:
Not classified as hazardous.

Routes of entry:
Eye contact, Skin contact

Carcinogenic status:
Not considered carcinogenic by NTP, IARC, and OSHA.

Target organs:
Eye, skin

Health Effects - Eyes
Contact may cause slight transient irritation.

Health effects - Skin
Material may cause irritation.

Health Effects - Ingestion
No adverse effects are expected. 
 
Health Effects - Inhalation
No adverse effects are expected during normal conditions of use.  
Inhalation of paraffin wax fumes during heating may irritate the eyes, nose
and throat.


Section 4: First Aid Measures


Eyes
Immediately flood the eye with plenty of water for at least 15 minutes,
holding the eye open.  Obtain medical attention if soreness or redness
persists.  

Skin
If skin irritation develops, or other symptoms occur, discontinue use.  
Seek medical attention if symptoms persist. Contaminated clothing should be
washed or dry-cleaned before re-use. 

Ingestion
Do not induce vomiting.  Have victim drink 1-3 glasses of water to dilute stomach
contents. Never administer anything by mouth if a victim is losing consciousness, 
is unconscious or is convulsing. Obtain medical attention immediately. 

Inhalation
If there is difficulty in breathing, give oxygen.  Seek medical attention if
symptoms persist.

Advice to Physicians:  Treat symptomatically. 


Section 5: Fire Fighting Measures


Extinguishing Media
Not Flammable.  Select extinguishing agent appropriate to other materials involved. 

Unusual Fire and Explosion Hazards
This product may give rise to hazardous fumes in a fire. 

Protective Equipment for Fire-Fighting
Wear NIOSH/MSHA approved positive pressure self-contained breathing
apparatus and full protective clothing.


Section 6: Accidental Release Measures


This product may be collected by carefully scooping into a pan, paper towel
or other absorbent material.  If wax is hot, let cool before initiating
clean-up.  To clean-up spills of cooled wax, use nonsparking tools to scrape
the wax into suitable containers for disposal.  Wear appropriate protective
clothing. 




Section 7: Handling and Storage



Keep container tightly closed when not in use.
Storage area should be: - cool - dry - well ventilated - away from incompatible
materials  

Storage Recommendations:
Store in a cool, dry area, away from direct heat or sunlight.  If intended for food 
or pharmaceutical packaging applications, keep away from pesticides, PCBs and other
hazardous chemicals.



Section 8: Exposure Controls and Personal Protection


Occupational Exposure Standards
     Polyisobutylene                 Paraffin (fume)

     None assigned.          ACGIH: TLV 2mg/m3 8h TWA.UK
                              EH40: OES 2mg/m3 8h TWA.UK
                              EH40: OES 6mg/m3 10min TWA.

Engineering Control Measures
No specific measures necessary.  Good general room ventilation is expected to be
adequate to control airborne levels.  Heating of this product may generate vapors
or fumes, therefore, local exhaust ventilation is recommended to keep airborne
concentrations below exposure limits.   

Respiratory Protection
Respiratory protection if there is risk of breathing mists or vapors from
heated material.  The specific respirator selected must be based on the
airborne concentration found in the workplace and must not exceed the
working limits of the respirator. 
  
Hand Protection
Chemical resistant gloves  

Eye Protection
Chemical goggles  or safety glasses with side shields 

Body Protection
Normal work wear.


Section 9: Physical and Chemical Properties


Physical State:              Waxy  Pellets  
Color Colorless:             White  - Translucent
Odor:                        Odorless
pH:                          No data
Specific Gravity:            0.80
Boiling Range/Point (°C/F):  No data
Melting Point (°C/F):        47-65 / 117-149 (depending on grade)
Flash Point (PMCC) (°C/F):   210 / 410
Auto-flammability (deg C):   245 (for 100% paraffin)
Explosion Limits (%):        No data
Vapor Pressure:              No data
Density:                     No data
Solubility in Water:         Insoluble
Vapor Density (Air = 1):     No data
Viscosity (cSt):             No data


Section 10: Stability and Reactivity



Stability:
Stable under normal conditions. 

Conditions to Avoid:
Heat  - High temperatures - Pressure - Mechanical shock  

Materials to Avoid:
Reducing agents - Strong acids  

Hazardous Polymerization:
Will not occur. 
  
Hazardous Decomposition Products:
acrid smoke and irritating fumes  



Section 11: Toxicological Information


Acute Toxicity
Low order of acute toxicity predicted. Paraffin:  A 100 mg dose applied to
the rabbit eye for 24 hours caused mild irritation.  A 500 mg dose applied
to the rabbit skin for 24 hours caused mild irritation.

Chronic Toxicity/Carcinogenicity
Paraffin:  When implanted in rats (120 mg/kg) and mice (480-660 mg/kg),
caused tumors of the bladder, lungs and thorax.

Genotoxicity
This product is not expected to cause any mutagenic effects.
Reproductive/Developmental Toxicity

This product is not expected to cause reproductive or developmental health
effects.



Section 12: Ecological Information


Mobility
No relevant studies identified. 

Persistence/Degradability
No relevant studies identified.

Bio-accumulation
No relevant studies identified. 

Ecotoxicity
No relevant studies identified. 



Section 13: Disposal Considerations



Dispose of in accordance with all applicable local and national regulations.


RCRA
Is the unused product a RCRA hazardous waste if discarded?  No.

The information offered here is for the product as shipped.  Use and/or
alterations to the product such as mixing with other materials may
significantly change the characteristics of the material and alter the
RCRA classification and the proper disposal method.




Section 14: Transport Information


DOT CFR 172.101 Data     Not Regulated 
UN Proper Shipping Name  Not Regulated 
UN Class                 None 
UN Number                None
UN Packaging Group       None



Section 15: Regulatory Information


Labelling Information - Environment

EC Annex I Classification
According to EC Commission Directive 67/548/EEC this product is not classified.

R phrases
None.

S phrases
None.

TSCA Listing
All ingredients have been verified for inclusion on the EPA Toxic Substance
Control Act Chemical Substance Inventory.

EINECS Listing
All ingredients in this product are listed on the European Inventory of
Existing Commercial Chemical Substances (EINECS) or the European List of New
Chemical Substances (ELINCS) or are exempt from listing.

DSL/NDSL (Canadian) Listing
All ingredients in this product are listed on the Domestic Substance List
(DSL) or the Non-Domestic Substance List (NDSL).

MA Right To Know Law
All components have been checked for inclusion on the Massachusetts
Substance List (MSL).   Those components present at or above the de minimus
concentration include: - Paraffin

PA Right To Know Law
This product contains the following chemicals found on the Pennsylvania Hazardous
Substance List:  - Paraffin  

NJ Right To Know Law
This product does not contain any chemicals on the New Jersey Workplace
Hazardous Substance List.  

California Proposition 65:
Proposition 65 requires manufacturers or distributors of consumer products
into the State of California to provide a warning statement if the product
contains ingredients for which the State has found to cause cancer, birth
defects or other reproductive harm.  If this product contains an ingredient
listed by the State of California to cause cancer or reproductive toxicity,
it will be listed below:

No products

SARA Title III Sect. 302 (EHS)
This product does not contain any chemicals subject to SARA Title III
Section 302. 
 
SARA Title III Sect. 304
This product does not contain any chemicals subject to SARA Title III
Section 304.  
 
SARA Title III Sect. 311/312 Categorization
Immediate (Acute) Health Hazard 

SARA Title III Sect. 313
This product does not contain a chemical which is listed in Section 313 at
or above de minimis concentrations. 

WHMIS Classification (CANADA):
Not a controlled substance.  (Considered to be a manufactured article.)



Section 16: Other Information

Disclaimer of Liability:
Caution! Do not use SPI Supplies products or materials in applications involving implantation within the body; direct or indirect contact with the blood pathway; contact with bone, tissue, tissue fluid, or blood; or prolonged contact with mucous membranes. Products offered by SPI Supplies are not designed or manufactured for use in implantation in the human body or in contact with internal body fluids or tissues. SPI Supplies will not provide to customers making devices for such applications any notice, certification, or information necessary for such medical device use required by US FDA (Food and Drug Administration) regulation or any other statute. SPI Supplies and Structure Probe, Inc. make no representation, promise, express warranty or implied warranty concerning the suitability of these materials for use in implantation in the human body or in contact with internal body tissues of fluids.

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The information and recommendations set forth above are taken from sources believed to be accurate as of the date hereof, however SPI Supplies and Structure Probe, Inc. make no warranty with respect to the accuracy of the information or the suitability of the recommendations, and assume no liability to any user thereof. The information contained in this sheet does not constitute a hazard assessment and should not be used in place of the user's own assessment of work place risks as required by other health and safety legislation.

Be aware of the Structure Probe, Inc. Copyright Policy. Structure Probe, Inc. grants a nonexclusive license to make unlimited copies of this safety sheet for internal use only. Quite obviously, this information would pertain only to this material when purchased from SPI Supplies as product from other sources, with other ingredients and impurity levels could have substantially different properties.

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