SPI Supplies SPI Supplies Division
Structure Probe, Inc.

P.O. Box 656 West Chester, PA 19381-0656 USA
Phone: 1-(610)-436-5400 Fax: 1-(610)-436-5755
E-mail: spi3spi@2spi.com

WWW: http://www.2spi.com
Manufacturer's CAGE: 1P573

Material Safety Data Sheet

SPI #02694-AB, 02694-BC Cryo-Gel™




Section 1: Identification

Date Effective........... January 8, 2009
                          (most recent revision)

Chemical Name/Synonyms... Cryo-Gel™

Emergencies                
Contacting CHEMTREC:

24 Hour Emergency Use Only #'s... 
Worldwide phone: 1-(703)-527-3887
Worldwide FAX:   1-(703)-741-6090 
Toll-free phone: 1-(800)-424-9300 USA only


Product or Trade Name.... SPI #02694-AB, 02694-BC  Cryo-Gel™
Synonyms................. Water Soluble Media for Frozen Sections


Hazardous Material
Information System
USA
Health 1 National Fire
Protection Association
USA
Fire Hazard 1
Reactivity 0
Personal Protection  
NFPA Rating: (estimated) Health: ; Flammability: ; Reactivity:

Section 2: Composition

Component Name            CAS #          Percent       EINECS/ELINCS
Sucrose                   57-50-1        n/a           200-334-9
Water                     7732-18-5      n/a           231-791-2
Hydroxyethylcellulose     9004-62-0      n/a           n/a

n/a=not available

Section 3: Hazard Identification

Emergency overview:
May cause eye, skin, and respiratory tract irritation.

Appearance: 
Clear liquid

Flash Point:    
Not available

Potential Health Effects

Eye:
May cause eye irritation.

Skin:
May cause skin irritation.

Ingestion:
Not available

Inhalation:
May cause respiratory irritation.

Chronic:
Not available.

Section 4: First Aid Measures

Eyes:
Flush eyes with copious amounts of water for at least 15 minutes, holding
the eyelids open.  If irritation develops, seek medical attention.

Skin:
Flush skin with copious amounts of soap and water.  If irritation develops,
seek medical attention.

Ingestion:
Do not induce vomiting.  Give 2 to 4 cupfuls of water or milk if victim is 
conscious and alert. If irritation or symptoms occur, seek medical attention.

Inhalation:
Remove to fresh air. If breathing is difficult, give oxygen.  If breathing
stops, give artificial respiration. If cough or other symptoms occur, seek
medical attention.

Notes to Physician:
Treat symptomatically and supportively.

Section 5: Fire Fighting Measures

General Information:
Wear a NIOSH approved positive pressure self-contained breathing apparatus 
and firefighter turnout gear.  This should be selected on the basis of the
supporting fire.


Extinguishing Media:
Use extinguishing media appropriate to the surrounding fire.


Section 6: Accidental Release Measures

General Information:
No special measures are indicated.

Spills/Leaks:
No special measures are indicated.

Section 7: Handling and Storage

Handling:
Minimize dust generation.

Storage:
Store at ambient room temperature in original container.

Section 8: Exposure Controls and Personal Protection

Engineering Controls:
Use with adequate ventilation.  Eye wash station should be available to the
work area.

Exposure Limits:

Chemical Name                   
Sucrose  ACGIH:10 mg/m3 TWA
         NIOSH:10 mg/m3 TWA (total dust); 
                5 mg/m3 TWA (respirable dust)
         OSHA - Final PELS: 15 mg/m3 TWA (total dust);
                             5 mg/m3 TWA (respirable fraction)

OSHA Vacated PELs: 
Sucrose: 15 mg/m3 TWA(total dust); 
          5 mg/m3 TWA(respirable fraction)

Personal Protective Equipment

Eyes: 
Safety glasses with side shields
Skin: 
Suitable gloves to prevent skin exposure
Clothing: 
Suitable clothing to prevent skin exposure
Respirators:
If exposure limits are exceeded, or if symptoms of irritation are experienced, use 
use a NIOSH/MSHA or European Standard EN 149 approved respirator.  Follow the OSHA
respirator regulations found in 29 CFR 1910.134.
°3

Section 9: Physical and Chemical Properties

Physical State: Liquid
Appearance: Clear, colorless
Odor: n/a
pH: n/a
Vapor Pressure: n/a 
Vapor Density: n/a
Evaporation Rate: n/a
Viscosity: n/a
Boiling Point: n/a
Freezing/Melting Point:Autoignition Temperature: n/a
Flash Point: n/a
Decomposition Temperature: n/a
Explosion Limits:
        Lower: n/a
        Upper: n/a
Solubility in water: Soluble
Specific Gravity/Density: n/a
Molecular Formula: n/a
Molecular Weight: n/a

n/a = not available

Section 10: Stability and Reactivity

Chemical Stability:
Stable

Conditions to Avoid:
Excess heat, dust generation

Incompatibility with Other Materials:
Strong oxidizers

Hazardous Decomposition of Products:
Carbon dioxide, carbon monoxide

Hazardous Polymerization:
Will not occur

Section 11: Toxicological Information

RTECS#:
CAS#:57-50-1: WN6500000

LD50/LC50 Information:
CAS#: 57-50-1:
         LD50               Rat, oral             29700 mg/kg
CAS#: 9004-62-0: No data available 

Carcinogenicity:
CAS# 57-50-1: Not listed by ACGIH, IARC, NTP, or CA Prop 65
CAS# 9004-62-0: Not listed by ACGIH, IARC, NTP, or CA Prop 65
 
Teratogenicity:
Not available

Reproductive Effects:
Not available

Neurotoxicity:
Not available

Mutagenicity:
Not available

Other Studies:
Not available


Section 12: Ecological Information

Biodegradable.
Soluble in water.
No further information available.

Section 13: Disposal Considerations

RCRA P-Series: Not listed
RCRA U-Series: Not listed

Dispose of in compliance with all federal, state, and local environmental 
regulations.

Section 14: Transport Information

US DOT Hazard Class:Not hazardous for transport.

IATA (for international shipments):Not hazardous for transport


Section 15: Regulatory Information

United States:

TSCA
All components of this product are listed on the TSCA Inventory List.

Health & Safety Reporting List
None of the components of this product are on the Health & Safety Reporting
List.

Chemical Test Rules
None of the components of this product are under a Chemical Test Rule.

Section 12b:
None of the components of this product is on the TSCA Section 12b List.

TSCA Significant New Use Rule:
None of the components of this product is under the Significant New Use Rule. 

CERCLA Section 103:SARA:

Section 302 (RQ)
None of the components of this product has an RQ.

Section 302 (TPQ)
None of the components of this product has a TPQ.

SARA Codes
None of the components of this product is listed.

Section 313
None of the components of this product is listed under Sara Section 313.

Clean Air Act:
None of the components of this product is listed under the Clean Air Act.

Clean Water Act:
None of the components of this product is listed under the Clean Water Act.

OSHA:
None of the components of this product is considered hazardous by OSHA.

State (Individual states in the USA)
CAS# 57-50-1 is listed on the Massachusetts, Minnesota and Pennsylvania
state right to know lists.

California No Significant Risk Level:
None of the components of this product is listed.

California Prop. 65:
None of the components of this product is listed uncer Calif. Prop. 65.
  

European/International Regulations:
European Labeling in Accordance with EC Directives

Hazard Symbols: Not available
Risk Phrases: Not available     
Safety Phrases: Not available
 
WGK (Water Danger/Protection): Not available

Canada

This product has a WHMIS classification of Not Controlled.

DSL/NDSL
CAS# 57-50-1 is listed on the DSL List.
CAS# 7732-18-5 is listed on the DSL List.
CAS# 9004-62-0 is listed on the DSL List.



Section 16: Other Information

If this product should be used in ways that are outside of the intended applications in scanning electron microscope laboratories, and if it is going to be formulated into some other system, so that it becomes just another component of that other system, read the MSDS sheets for the other components before blending as the resulting mixture may have the hazards of all of its parts.

Disclaimer of Liability:

Caution! Do not use SPI Supplies products or materials in applications involving implantation within the body; direct or indirect contact with the blood pathway; contact with bone, tissue, tissue fluid, or blood; or prolonged contact with mucous membranes. Products offered by SPI Supplies are not designed or manufactured for use in implantation in the human body or in contact with internal body fluids or tissues. SPI Supplies will not provide to customers making devices for such applications any notice, certification, or information necessary for such medical device use required by US FDA (Food and Drug Administration) regulation or any other statute.

SPI Supplies and Structure Probe, Inc. make no representation, promise, express warranty or implied warranty concerning the suitability of these materials for use in implantation in the human body or in contact with internal body tissues of fluids.

************************************************************************

The information and recommendations set forth above are taken from sources believed to be accurate as of the date hereof, however SPI Supplies and Structure Probe, Inc. make no warranty with respect to the accuracy of the information or the suitability of the recommendations, and assume no liability to any user thereof. The information contained in this sheet does not constitute a hazard assessment and should not be used in place of the user's own assessment of work place risks as required by other health and safety legislation. Be aware of the Structure Probe, Inc. Copyright Policy. Structure Probe, Inc. grants a nonexclusive license to make unlimited copies of this safety sheet for internal use only. Quite obviously, this information would pertain only to this material when purchased from SPI Supplies as product from other sources, with other ingredients and impurity levels could have substantially different properties.


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