Information System
USA
Protection Association
USA
SPI Supplies Division
Date Effective........... June 21, 2007
(most recent revision)
Chemical Name/Synonyms... Formalin; Formaldehyde buffered solution
Emergencies
Contacting CHEMTREC:
24 Hour Emergency Use Only #'s...
Worldwide phone: 1-(703)-527-3887
Worldwide FAX: 1-(703)-741-6090
Toll-free phone: 1-(800)-424-9300 USA only
Product or Trade Name.... SPI # 02613-AB
| Hazardous Material Information System USA |
Health | 2 | National Fire Protection Association USA |
|
| Fire Hazard | 0 | |||
| Reactivity | 0 | |||
| Personal Protection |
Component Name CAS # Percent EU # Formaldehyde 50-00-0 3.65-3.8 200-001-8 Methyl Alcohol 67-56-1 1-1.5 200-659-6 Water 7732-18-5 93.2-93.8 231-791-2 Sodium Phosphate monobasic, anhydrous 7558-80-7 0.5 231-449-2 Sodium Phosphate, dibasic 7558-79-4 1 231-448-7
Emergency overview: This product contains formaldehyde, which is a confirmed carcinogen in humans. This product also contains methyl alcohol which may cause blindness. Reaction with oxidizing agents such as peroxides or nitrogen dioxide may cause an explosion. Appearance: Clear, colorless liquid. Flash Point: None. Warning! Target Organs: Skin, eyes, liver, kidneys, heart, endocrine system, central nervous system. Potential Health Effects Eye: May cause irritation upon contact. Skin: May be absorbed through skin, causing symptoms analogous to ingestion symptoms. May cause skin irritation or sensitization. Ingestion: May cause gastrointestinal irritation. May cause nausea, vomiting, diarrhea, pain in mouth/throat/stomach. May affect liver (jaundice), urinary system/kidneys (difficulty urinating, albuminuria, hematuria, anuria), blood, endocrine system, respiration (respiratory obstruction, pulmonary edema, bronchiolar obstruction), cardiovascular system (hypotension), metabolism (metabolic acidosis), eyes (retinal changes, visual field changes), and central nervous system. This product contains methanol, which may cause blindness if ingested. Inhalation: While no conclusive evidence has been determined, prolonged exposure may induce allergic asthma. Chronic: May cause irritation/allergic skin dermatitis or skin discoloration. Repeated ingestion may cause gastrointestinal tract irritation and symptoms analogous to acute ingestion symptoms.
Eyes: Upon contact, wash eyes throughly with copious amounts of water for
at least 15 minutes, holding the eyes open. Seek medical attention immediately.
Skin: Flush area with copious amounts of water. Remove contaminated clothing,
wash thoroughly with soap and water. Cover the irritated skin with an emollient.
If irritation persists, seek medical attention.
Ingestion: Upon ingestion, dilute with 2-4 glasses of water or milk.
Do not induce vomiting. Seek medical attention.
Inhalation: Remove victim to fresh air. If not breathing, provide artificial
respiration. If breathing is difficult, provide oxygen. Seek medical immediately.
Notes to Physician: This product contains 1 - 1.5% by weight methanol.
Notes for methanol poisoning include the following:
A. Support vital functions, correct for dehydration and shock, managing
fluid balance.
B. Current recommended medical management of methanol poisoning include
the following:
i. Emptying the stomach by gastric lavage. Useful if initiated within
< 1 of ingestion.
ii. Correct metabolic acidosis with intravenous administration of
sodium bicarbonate, adjusting the administration rate according
to repeated and frequent measurement of acid/base status.
iii. Administer ethanol (orally or intravenously) or Fomepizole
(4-methylpyrazole or Antizol) therapy by IV as an andidote
to inhibit the formation of toxic metabolites. Adjunct therapy
with Leucorvin followed by Folate can also be initialized. Please
note that if ethanol therapy is used, monitor blood glucose,
especially in children. Ethanol can cause hypoglycemia.
iv. If patients are diagnosed and treated early in the course with
the above methods, hemodialysis may be avoided if fomepizole
or ethanol therapy is effective and has corrected the metabolic
acidosis, and no renal failure is present. However, once severe
acidosis and renal failure have occurred, hemodialysis is necessary.
Hemodialysis is effective in removing methyl alcohol and toxic
metabolites, and correcting metabolic acidosis.
Flammability: Not flammable. Autoignition Temperature: N/A Flash Point: None. General Information: Wear full protective equipment including self containing breathing apparatus. Extinguishing Media: Carbon dioxide, dry chemical, foam, water spray. Unusual Fire/Explosion Hazards: None. Hazardous combustion products: None. Protection of fire fighters: No special measures are required.
General Information: In case of a leak or spill, clear area immediately. Appropriate protective equipment should be worn at all times, including a self-contained breathing device, rubber boots, and heavy rubber gloves. Spills/Leaks: Absorb on sand or vermiculite and place in closed containers for waste disposal. Ventilate contaminated area well, and wash site after cleanup is complete. Do not allow product to enter sewer, drains, or other waterways.
Handling: Do not breathe vapor. Avoid contact with eyes, skin, and clothing. Local exhaust or process enclosure ventilation should be employed at all times. If exposure limits may be exceeded, use a full-face respirator with multi-purpose LUSN or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. Keep out of the reach of children. Storage: Store away from strong oxidizers, extreme temperatures, sparks, and open flames.
Engineering Controls: Exhaust or other forms of ventilation should be employed
to keep vapor levels below threshold limit values. Safety shower and eye wash stations
should be readily accessible in work area.
Exposure Limits
Formaldehyde gas:
STEL: 0.3 ppm (ACGIH, TLV)
STEL: 0.37 mg/m3 (ACGIH, TLV)
TWA: 0.75 STEL: 2 ppm (OSHA, PEL)
TWA: 2 STEL: 2 ppm (United Kingdom)
TWA: 2.5 STEL: 2.5 mg/m3 (United Kingdom)
Methyl Alcohol:
TWA: 200 (OSHA, PEL)
TWA: 200 STEL: 250 ppm (ACGIH, TLV)
STEL: 250 (NIOSH)
TWA: 200 STEL: 250 ppm (NIOSH, SKIN)
TWA: 200 STEL: 250 ppm (Canada)
Personal Protective Equipment
Eyes: Glasses with side shields or chemical splash goggles.
Skin: As necessary to prevent skin contact.
Clothing: Protective clothing such as long sleeves or a lab coat
should be worn. Neoprene or nitrile gloves are recommended. When handling
heated materials, also be sure to use heat-resistant gloves, boots and face
protection.
Respirators: If exposure limit may be exceeded, use a NIOSH/MSHA or European
standard EN149 respirator as found in OSHA Regulation 29 CFR 1910.134 or European
standard EN 149.
Physical State: Liquid.
Appearance: Clear, colorless liquid.
Odor: Pungent.
pH: N/A
Vapor Pressure: 12.3 kPa @ 20° C (highest known value, methyl alcohol).
Weighted average: 2.43 kPa @ 20° C.
Vapor Density: 1.11 (highest known value, methyl alcohol).
Weighted average: 0.63 (air = 1).
Evaporation Rate: >1 (diethyl ether = 1).
Viscosity: N/A
Boiling Point: 64.5° C (lowest known value, methyl alcohol).
Weighted average = 99.53° C (211.2° F).
Freezing/Melting Point: May start to solidify @ -97.8° C (-144° F).
Based on data for methyl alcohol.
Autoignition Temperature: N/A
Flash Point: None.
Decomposition Temperature: N/A
Explosion Limits
Lower: N/A
Upper: N/A
Solubility in water: 100%
Specific Gravity/Density: 1 g/mL (water = 1).
Molecular Formula: N/A
Molecular Weight: N/A
Chemical Stability: Stable under normal conditions.
Conditions to Avoid: Incompatible materials.
Incompatibility with Other Materials: Acids.
Acid Chlorides.
Acid Anhydrides.
Oxidizing Agents.
Alkali Metals.
Reducing Agents.
Amines.
Peroxides.
Hazardous Decomposition of Products: Thermal decomposition may release
toxic and/or hazardous fumes.
Hazardous Polymerization: Will not occur.
Routes of Entry: Absorption through skin, eye contact, inhalation, and ingestion.
Toxicity to Animals:
Acute Oral Toxicity (LD50)..... 42 mg/kg (formaldehyde gas, mouse).
Acute Dermal Toxicity (LD50)... 15,800 mg/kg (methyl alcohol, rabbit).
Acute Dermal Toxicity (LD50)... 270 uL/kg (formaldehyde gas, rabbit).
Teratogenicity: Classified POSSIBLE for human (methyl alcohol). Contains
material that may cause damage to the following organs: kidneys, liver, skin,
central nervous system.
Carcinogenic Effects: Classified as A2 (suspected for humans) by ACGIH, 2A
(probable for human) by IARC (formaldehyde). IARC Rating: Group I.
Mutagenicity: Mutagenic for mammalian somatic cells (formaldehyde, methyl alcohol).
Mutagenic for bacteria and/or yeast (formaldehyde, methyl alcohol).
Other Studies: Skin contact may be hazardous (sensitizer, permeator, irritant).
Hazardous in case of ingestion or inhalation (lung irritant).
Exotoxicity: N/A Products of Biodegradation: Potentially hazardous short-term degradation products are not likely. Long-term degradation products may arise. Toxicity of Biodegradation Products: Degradation products are less toxic than the product itself.
Waste Disposal: In accordance with all local, state, and federal regulations. Contact a licensed professional waste disposal service. Dissolve or mix with combustible solvent and burn in chemical incinerator equipped with after-burner and scrubber.
US DOT Hazard Class: Not regulated. IATA (for international shipments): Not regulated.
United States
TSCA: All ingredients in this product are listed on the TSCA inventory.
CERCLA: Hazardous substances: Formaldehyde: 100 lbs (45.36 kg); Methyl Alcohol:
5000 lbs (2268 kgs); Sodium Phosphate, dibasic: 5000 lbs (2268 kg).
OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910. 1200).
For formaldehyde (CAS # 50-00-0).
SARA Hazard Codes
Sections 302/304/311/312: Extremely hazardous substances: Formaldehyde.
Section 313: Toxic chemical notification and release reporting: Formaldehyde,
3.725%; Methyl Alcohol, 1.25%.
State (Individual states in the USA)
California No Significant Risk Level: Formaldehyde Solution: 0.04 mg/day (inhalation).
California Prop. 65: This product contains the following ingredients for which
the State of California has found to cause cancer, birth defects, or other reproductive
harm, which would require a warning under the statute: Formaldehyde.
Connecticut Hazardous Material Survey: Formaldehyde; Methyl Alcohol, Sodium
Phosphate, dibasic.
Illinois Toxic Substances Disclosure to Employee Act: Formaldehyde; Methyl Alcohol.
Illinois Chemical Safety Act: Formaldehyde; Methyl Alcohol; Sodium Phosphate,
dibasic.
New York Release Reporting List: Formaldehyde; Methyl Alcohol; Sodium Phosphate,
dibasic.
Rhode Island RTK Hazardous Substances: Formaldehyde; Methyl Alcohol.
Pennsylvania RTK: Formaldehyde Gas; Methyl Alcohol; Sodium Phosphate,
dibasic.
Minnesota: Formaldehyde; Methyl Alcohol.
Massachusetts RTK: Formaldehyde; Methyl Alcohol; Sodium Phosphate, dibasic.
Massachusetts Spill List: Formaldehyde; Methyl Alcohol.
New Jersey: Formaldehyde Gas; Methyl Alcohol; Sodium Phosphate,
dibasic.
New Jersey Spill List: Formaldehyde; Methyl Alcohol; Sodium Phosphate,
dibasic.
Louisiana RTK Reporting List: Formaldehyde.
Louisiana Spill Reporting: Formaldehyde; Methyl Alcohol; Sodium Phosphate,
dibasic.
California Director's List of Hazardous Substances: Formaldehyde Gas; Methyl Alcohol.
European/International Regulations
Hazard Symbols: Xn Harmful
Risk Phrases:
R36/37/38 Irritating to eyes, respiratory system and skin.
R40 Possible risks of irreversible effects.
R43 May cause sensitization by skin contact.
Safety Phrases:
S2 Keep out of the reach of children.
S26 In case of contact with eyes, rinse immediately with plenty of water and
seek medical attention.
S36/37 Wear suitable protective clothing and gloves.
Canada
WHMIS: This product has a WHMIS classification of D2B: Material causing
other toxic effects (TOXIC).
DSL/NDSL Status: All components of this product appear on the DSL.
If this product should be used in ways that are outside of the intended applications in scanning electron microscope laboratories, and if it is going to be formulated into some other system, so that it becomes just another component of that other system, read the MSDS sheets for the other components before blending as the resulting mixture may have the hazards of all of its parts.
Disclaimer of Liability:
Caution! Do not use SPI Supplies products or materials in applications involving implantation within the body; direct or indirect contact with the blood pathway; contact with bone, tissue, tissue fluid, or blood; or prolonged contact with mucous membranes. Products offered by SPI Supplies are not designed or manufactured for use in implantation in the human body or in contact with internal body fluids or tissues. SPI Supplies will not provide to customers making devices for such applications any notice, certification, or information necessary for such medical device use required by US FDA (Food and Drug Administration) regulation or any other statute.
SPI Supplies and Structure Probe, Inc. make no representation, promise, express warranty or implied warranty concerning the suitability of these materials for use in implantation in the human body or in contact with internal body tissues of fluids.
The information and recommendations set forth above are taken from sources believed to be accurate as of the date hereof, however SPI Supplies and Structure Probe, Inc. make no warranty with respect to the accuracy of the information or the suitability of the recommendations, and assume no liability to any user thereof. The information contained in this sheet does not constitute a hazard assessment and should not be used in place of the user's own assessment of work place risks as required by other health and safety legislation. Be aware of the Structure Probe, Inc. Copyright Policy. Structure Probe, Inc. grants a nonexclusive license to make unlimited copies of this safety sheet for internal use only. Quite obviously, this information would pertain only to this material when purchased from SPI Supplies as product from other sources, with other ingredients and impurity levels could have substantially different properties.
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