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Material Safety Data Sheet

SPI #02524-AA, 02524-NA, 02524-AB Propylene oxide



Spanish




Section 01 Identification

Date Effective........... January 8, 2009
                          (most recent revision)

Chemical name ........... Propylene oxide

Synonyms................. Methyl ethylene oxide; Methyloxirane; 
                          1,2-Epoxypropane

Product or Trade Name.... SPI # 02524-AA, 02524-AB, and 02524-NA 
                          Propylene oxide

CAS #.................... 75-56-9

Chemical Formula......... CH3CHCH2O

Emergencies               Contacting CHEMTREC 24 Hour Emergency 
Use Only #'s............. Worldwide phone : 1-(703)-527-3887
                          Worldwide FAX   : 1-(703)-741-6090
                          Toll-free phone : 1-(800)-424-9300 USA only
Hazardous Material
Information System
USA
Health 3 National Fire
Protection Association
USA
Fire Hazard 4
Reactivity 2
Personal Protection
NFPS Rating:
Health: 3       Flammability: 4      Instability: 2


Section 2 Composition / Information on Ingredients

CAS #.................... 75-56-9  - More than 98%



Section 3: Hazard Identification

Clear, colorless liquid. Flash Point: -37 F.  Extremely flammable 
liquid and vapor. May cause flash fire.

Potential health effects (acute and chronic): May cause allergic skin
reaction. Causes severe eye and skin irritation.  Causes respiratory
tract irritation. Aspiration hazard if swallowed; may enter lungs and
cause damage. Harmful if inhaled, swallowed, or absorbed through skin. 
May cause cancer.

Target Organs: Lungs, respiratory system, eyes, skin, mucous membranes.

Symptoms of exposure:

   Effects of eye exposure: Causes eye irritation. May cause burning 
   sensation, redness, tearing, inflammation, and possible corneal damage. 
   May cause blindness.  Vapors may cause eye injury.

   Effects of skin contact: May cause skin sensitization, an allergic 
   reaction. May be harmful if absorbed through the skin. Causes severe skin 
   irritation and possible burns, including blisters.   May cause more severe 
   response under clothing, gloves.  Aqueous solutions may cause more severe 
   effects, including burns.
   
   Effects of ingestion:  Harmful if ingested. Causes gastrointestinal 
   irritation with nausea, vomiting and diarrhea. Aspiration of material into
   lungs may cause chemical pneumonitis, which may be fatal.

   Effects of inhalation:  Inhalation of high concentrations may cause 
   central nervous system effects characterized by nausea, headache,  
   dizziness, unconsciousness and coma.  Causes respiratory tract irritation. 
   Vapors may cause dizziness or suffocation.  Odor is not a sufficient 
   warning of concentrations exceeding the exposure guideline.
   
   Chronic Effects: Prolonged or repeated skin contact may cause dermatitis. 
   Chronic inhalation may cause respiratory tract irritation and lung damage.
   A possible weak carginogenic effect has been noted in lifetime inhalation 
   studies of laboratory animals.


Section 4: First Aid Measures
    Eyes: Immediately flush thoroughly with water for at least 15 minutes,
    occasionally lifting the upper and lower eyelids. Get medical aid
    immediately.

    Skin: Flush skin with plenty of soap and water for at least 15 minutes,
    while removing contaminated clothing and shoes.  Wash clothing
    thoroughly before reusing. Get medical aid immediately.  
    
    Inhalation: Get medical aid immediately. Remove to fresh air immediately.
    Give artificial respiration if breathing has stopped. If breathing is
    difficult, give oxygen. Get medical aid immediately.

    Ingestion:  Potential for aspiration if swallowed. Do NOT induce
    vomiting, unless directed to do so by medical personnel. Never give
    anything by mouth to an unconscious person. Get medical aid
    immediately.

    Notes to Physician: Treat symptomatically and supportively.


Section 5: Fire Fighting Measures
Flash Point.................... -37 F
Autoignition Temperature: . . . 840.2 F
Explosion Limits . . .Lower . . 2.3 volume %
                 . . .Upper . . 37 volume %

Fire Extinguishing Media:
    Use flooding quantities of water as spray.  Use water spray, dry 
    chemical, carbon dioxide, or alcohol-resistant foam.

Fire Fighting Procedure:
    Extremely flammable liquid and vapor. Vapor may cause flash fire.
    Hazardous polymerization may occur under fire conditions.
    Evacuate area and fight fire from a safe distance. Wear self-contained 
    breathing apparatus in pressure-demand, MSHA/NIOSH approved or
    equivalent, full protective gear. Vapors may form an explosive mixture 
    with air.  Use water spray to keep fire-exposed containers cool. Fire or 
    excessive heat may cause violent rupture of the container due to bulk 
    polymerization. Closed containers may rupture violently when heated.
    Vapors are heavier than air and may travel to a source of ignition and 
    flash back.  Vapors may collect in low or confined areas.


Section 6: Accidental Release Measures
Spill Response:
    
   General Information: Wear suitable protective equipment listed under 
   exposure/personal protection, including self contained breathing
   apparatus. 

   Spills/Leaks: Avoid runoff into storm sewers and ditches, which lead to 
   waterways. Avoid all sources of ignition. Provide ventilation. Absorb
   spill with an absorbent, non-combustible material such as earth or sand
   (not clay-based or vermiculite) and place in suitable container for proper 
   disposal, using a spark-proof tool. Approach spill from upwind.  Use water
   spray to cool and disburse vapors, protect personnel, and dilute spills to 
   form nonflammable mixtures.  Do not use clay-based absorbents.  Ground
   and bond containers and handling equipment.


Section 7: Handling and Storage
Handling: 
Use only in a well-ventilated area or with respiratory protection. Do not breathe
vapor.  Do not use air pressure to empty containers.  Refrigerate to 0C before
opening. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose
empty containers to heat, sparks or open flames. 

Take precautionary measures against static discharges. Ground and bond
containers when transferring material.  Use spark-proof tools and explosion
proof  equipment.  Avoid contact with heat, sparks and flame. Empty containers
may contain residue - do not pressurize, or expose empty containers to heat,
sparks or open flames. Keep tightly closed.

Avoid contact with eyes, skin and clothing. Wash thoroughly after handling.
Remove contaminated clothing and wash before reuse. Avoid ingestion or
inhalation.

Storage: 
Keep away from sources of ignition.  Keep away from heat, sparks, and flame. 
Store in a tightly closed container. Store in a flammables area, away from 
incompatible materials.  Store in cool, dry, well ventilated area. Storage under a
nitrogen blanket has been recommended.  Should not be exposed to temperatures
above 122 F.  Do not store product contaminated with water due to potential
for hazardous reaction.  Propylene oxide reacts with water to produce propylene
glycol, dipropylene glycol, tripropylene glycol and higher molecular weight polyglycols.



Section 8: Exposure Controls and Personal Protection
An eyewash facility and a safety shower should be available.  Use process
enclosure, local exhaust ventilation, or other engineering controls to control
airborne levels below recommended exposure limits.  Use explosion-proof ventilation
equipment.

Airborne Exposure Limits:
Chemical Name           ACGIH         NIOSH          OSHA - Final PEL 
Propylene oxide         2 ppm TWA     400 ppm TWA    100 ppm TWA
                        			     240 mg/m3 TWA

OSHA Vacated PELS:

Propylene oxide: 20 ppm TWA; 50mg/m3 = TWA

Personal Protective Equipment:

Eyes:  Wear chemical safety goggles and face shield as described by OSHA's eye and
face protection regulations in 29 CFR 1910.134 and ANSI Z88.2 requirements or the
European Standard EN149.

Skin: Wear appropriate protective gloves to prevent skin exposure.

Clothing:  Wear appropriate protective clothing to prevent skin exposure.

Respirators:  Follow the OSHA respirator regulations found in 29CFR 1910.134 and
ANSI Z88.2 requirements or the European Standard EN149 whenever workplace
conditions warrant a respirators use.


Section 9: Physical and Chemical Properties

Boiling Point.(760mm Hg). 34C   
Formula Weight..(g/mol).. 58.04       
pH (Liquids Only)........ not available
Melting Point............ -112C  
Vapor Pressure.(mm Hg)... 442 @20C 
Vapor Density/Air is 1... 2.0     
Solubility In Water...... soluble 
Appearance and Color..... colorless liquid
Specific Gravity(H2O=1):  0.83     
Evaporation Rate          not available
Odor..................... sweetish ether-like odor
Molecular Formula........ CH3CHCH2O



Section 10: Stability and Reactivity
Stable:  Stable under normal temperatures and pressures. 

Hazardous Polymerization: Will occur. May polymerize violently, especially
in the presence of aqueous sodium hydroxide, chlorine, ammonia, strong
oxidants, and acids.  

Hazardous Decomposition Products:  Carbon monoxide, Carbon dioxide, 
                                   irritating and toxic fumes and gases

Conditions to avoid: Ignition sources, temperatures above 50C or 122F, 
		     confined spaces

Materials to avoid: Strong oxidizing agents, acids, bases, amines, ammonia,
copper, copper alloys, iron, peroxides, catalytic metals, aluminum chloride,
ethylene oxide + polyhydric alcohol, anhydrous metal chloride, clay-based
absorbents, vermiculite


Section 11: Toxicological Information
RTECS #: CAS#  75-56-9: TZ2975000
	 

Toxicity data:                CAS# 75-56-9   
  Draize test, Rabbit, eye:   20mg Severe	    
  Draize test, Rabbit, eye:   20mg/24H Moderate   
  Draize test, Rabbit, skin:  50mg/6M Severe  
  Inhalation,Mouse LC50:      1740 ppm/4H     
  Inhalation, rat LC50:       4000 ppm/8H  
  Oral, Mouse LD50:           440 mg/kg        
  Skin, Rabbit LD50:          1500l/kg     
  Oral, rat LD50:             380 mg/kg     
 
Carginogenicity:
  CAS# 75-56-9: 
		ACGIH: A3- Confirmed animal carcinogen with unknown
                            relevance to humans
                California: Carcinogen, initial date 10/1/88
		NIOSH: Potential occupational carcinogen
		NTP: Suspect carcinogen
		OSHA: Possible select carcinogen
		IARC: Group 2B carcinogen

Edidemiology: Case reports of eczema and skin sensitization from exposure
   to propylene oxide have appeared in published literature.

Teratogenicity: Birth defects are unlikely.  Exposures having no effects on 
   the mother should have no effects on the fetus.  Did not cause birth 
   defects in animals.

Reproductive effect:
   Did not interfere with reproduction in animal studies.
	
Neurotoxicity: Rats exposed to 1500 ppm for 6 hours a day, 5 days a week,
   for 7 weeks developed ataxia in the hind legs with axonal degeneration of 
   the myelinated fibers in the hindleg nerve and fasciculus gracilis.

Mutagenicity: 
   In vitro mutagenicity studies were positive.  Animal mutagenicity studies
   were predominantly negative.  In a fruit fly assay with exposures of 645
   ppm, mutagenic effects were seen.


Section 12: Ecological Information
Ecotoxicity:
Fish:
 Goldfish: LC50    170 mg/L; 24h	
 Bluegill/Sunfish TLM 215 mg/l; 96h		 
 
Environmental:
    Terrestrial: If released to the soil, propylene oxide is expected to be
    susceptible to leaching and chemical hydrolysis in moist soils.  It is
    expected to evaporate relatively rapidly from dry soil surfaces.  If
    released to water, propylene oxide will hydrolyze.  Volatilization of
    propylene oxide from the aquatic environment may be an important
    transport mechanism.

    Atmospheric: If released to the atmosphere, will react in the vapor phase
    with photochemically produced hydroxyl radicals with an estimated half-life
    of approximately 30 days. Removal via rainfall may occur.  Bio-concentration
    in aquatic organisms, adsorption to sediment, or reaction with
    photochemically produced hydroxyl radicals in water are not expected to be
    environmentally important processes.


Section 13: Disposal Considerations
Consult state and local hazardous waste regulations to ensure complete and 
accurate classification.

US EPA guidelines for hazard classification determination are listed 
in 40 CFR Parts 261.3. 

RCRA P-Series: Not listed
RCRA U-Series: Not listed


Section 14: Transport Information
                      US DOT 			CAN.TDG    
Shipping Name         Propylene Oxide		Propylene Oxide	
Hazard Class            3                         3          
UN Number             UN1280    		UN1280    
Packing Group           I                         I         
Flash Point                      		-37C


Section 15: Regulatory Information

US FEDERAL:

TSCA
	CAS# 75-56-9 is listed on the TSCA inventory.
 
Health & Safety Reporting List
	CAS# 75-56-9: Effective 10/4/82; /Sunset 10/4/92

Chemical Test Rules
	Not listed

Section 12b
	Not listed

TSCA Significant New Use Rule
	Not listed on  SNUR under TSCA.

SARA
  CERCLA Hazardous Substances and Corresponding RQs
		CAS# 75-56-9: 100 lb final RQ; 45.4 kg final RQ
  SARA Section 302 (TPQ)
		CAS# 75-56-9: 10000 lb TPQ

SARA Codes
	CAS# 75-56-9: acute, chronic, flammable, reactive

Section 313
	CAS# 75-56-9 is subject to the reporting requirements of Section 313 
	of SARA Title III and 40 CFR Part 373.

Clean Air Act:
	CAS# 75-56-9 is listed as a hazardous air pollutant(HAP).  This material
	does not contain any Class 1 Ozone depletors.  This material does not
	contain any Class 2 Ozone depletors.

Clean Water Act:
	CAS# 75-56-9 is listed as a Hazardous Substance under the CWA. It is 
	not listed as a Priority Pollutant or as a Toxic Pollutant under the
	CWA.

OSHA:
	Not listed as highly hazardous by OSHA.

STATE:
	CAS# 75-56-9 can be found on the following state right to know lists: 
	California, New Jersey,Pennsylvania, Minnesota, Massachusetts.
	This product contains Propylene oxide, a chemical know to the State 
	of California to cause cancer.  California No Significant Risk Level: 
	None of the chemicals in this product are listed.

European/International Regulations

Hazard Symbols:
	CAS# 85-56-9: T F+

Risk Phrases:
	R12 Extremely flammable
	R20 Harmful by inhalation
	R21 Harmful in contact with skin
	R22 Harmful if swallowed
	R36 Irritating to eyes
	R37 Irritating to respiratory system
	R38 Irritating to skin
	R45 May cause cancer
	R46 May cause heritable genetic damage

Safety Phrases:
	S45 In case of accident or if you feel unwell, seek medical advice
	immediately (show label where possible).
	S53 Avoid exposure  obtain special instructions before use
	

WGK (Water Danger/Protection)
	75-56-9: 2

Canada - DSL/NDSL 
	75-56-9 is listed on Canada's DSL list.

Canada - WHMIS
	Has WHMIS classification of B2, D1B, D2A, D2B
	

Canada Ingredient Disclosure List
	Is listed on the Canadian Ingredient Disclosure List. 

Exposure Limits Around the World
    TWA for:        Propylene oxide		
Australia           20 ppm		
Belgium             20 ppm			
Denmark             5 ppm		
Finland             5 ppm		
France              20 ppm		
Germany             Carginogen			
The Netherlands     100 ppm		
The Philippines     100 ppm		
Russia              1 mg/m3		
Sweden              5ppm; STEL 10 ppm		
Switzerland         2.5 ppm		
Turkey              100 ppm	
United Kingdom      20 ppm; STEL 100 ppm
Bulgaria, Colombiia, Jordan, Korea - check ACGIH TLV OEL
New Zealand, Singapore, Vietnam  check ACGI TLV




Section 16: Other Information

Disclaimer of Liability:
Caution! Do not use SPI Supplies products or materials in applications involving implantation within the body; direct or indirect contact with the blood pathway; contact with bone, tissue, tissue fluid, or blood; or prolonged contact with mucous membranes. Products offered by SPI Supplies are not designed or manufactured for use in implantation in the human body or in contact with internal body fluids or tissues. SPI Supplies will not provide to customers making devices for such applications any notice, certification, or information necessary for such medical device use required by US FDA (Food and Drug Administration) regulation or any other statute. SPI Supplies and Structure Probe, Inc. make no representation, promise, express warranty or implied warranty concerning the suitability of these materials for use in implantation in the human body or in contact with internal body tissues of fluids.
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The information and recommendations set forth above are taken from sources believed to be accurate as of the date hereof, however SPI Supplies and Structure Probe, Inc. make no warranty with respect to the accuracy of the information or the suitability of the recommendations, and assume no liability to any user thereof. The information contained in this sheet does not constitute a hazard assessment and should not be used in place of the user's own assessment of work place risks as required by other health and safety legislation. Be aware of the Structure Probe, Inc. Copyright Policy. Structure Probe, Inc. grants a nonexclusive license to make unlimited copies of this safety sheet for internal use only. Quite obviously, this information would pertain only to this material when purchased from SPI Supplies as product from other sources, with other ingredients and impurity levels could have substantially different properties Should you have any questions about this, contact SPI Supplies.

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