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Section 01 Identification
Date Effective........... October 4, 2007
(most recent revision)
Chemical name ........... Propylene oxide
Synonyms................. Methyl ethylene oxide; Methyloxirane;
1,2-Epoxypropane
Product or Trade Name.... SPI # 02524-AA, 02524-AB, and 02524-NA
Propylene oxide
CAS #.................... 75-56-9
Chemical Formula......... CH3CHCH2O
Emergencies Contacting CHEMTREC 24 Hour Emergency
Use Only #'s............. Worldwide phone : 1-(703)-527-3887
Worldwide FAX : 1-(703)-741-6090
Toll-free phone : 1-(800)-424-9300 USA only
| Hazardous
Material Information System USA | Health | 3 | National Fire Protection Association USA |  |
| Fire Hazard | 4 | |||
| Reactivity | 2 | |||
| Personal Protection |
NFPS Rating: Health: 3 Flammability: 4 Instability: 2
CAS #.................... 75-56-9 - More than 98%
Clear, colorless liquid. Flash Point: -37 F°. Extremely flammable liquid and vapor. May cause flash fire. Potential health effects (acute and chronic): May cause allergic skin reaction. Causes severe eye and skin irritation. Causes respiratory tract irritation. Aspiration hazard if swallowed; may enter lungs and cause damage. Harmful if inhaled, swallowed, or absorbed through skin. May cause cancer. Target Organs: Lungs, respiratory system, eyes, skin, mucous membranes. Symptoms of exposure: Effects of eye exposure: Causes eye irritation. May cause burning sensation, redness, tearing, inflammation, and possible corneal damage. May cause blindness. Vapors may cause eye injury. Effects of skin contact: May cause skin sensitization, an allergic reaction. May be harmful if absorbed through the skin. Causes severe skin irritation and possible burns, including blisters. May cause more severe response under clothing, gloves. Aqueous solutions may cause more severe effects, including burns. Effects of ingestion: Harmful if ingested. Causes gastrointestinal irritation with nausea, vomiting and diarrhea. Aspiration of material into lungs may cause chemical pneumonitis, which may be fatal. Effects of inhalation: Inhalation of high concentrations may cause central nervous system effects characterized by nausea, headache, dizziness, unconsciousness and coma. Causes respiratory tract irritation. Vapors may cause dizziness or suffocation. Odor is not a sufficient warning of concentrations exceeding the exposure guideline. Chronic Effects: Prolonged or repeated skin contact may cause dermatitis. Chronic inhalation may cause respiratory tract irritation and lung damage. A possible weak carginogenic effect has been noted in lifetime inhalation studies of laboratory animals.
Eyes: Immediately flush thoroughly with water for at least 15 minutes,
occasionally lifting the upper and lower eyelids. Get medical aid
immediately.
Skin: Flush skin with plenty of soap and water for at least 15 minutes,
while removing contaminated clothing and shoes. Wash clothing
thoroughly before reusing. Get medical aid immediately.
Inhalation: Get medical aid immediately. Remove to fresh air immediately.
Give artificial respiration if breathing has stopped. If breathing is
difficult, give oxygen. Get medical aid immediately.
Ingestion: Potential for aspiration if swallowed. Do NOT induce
vomiting, unless directed to do so by medical personnel. Never give
anything by mouth to an unconscious person. Get medical aid
immediately.
Notes to Physician: Treat symptomatically and supportively.
Flash Point.................... -37 F°
Autoignition Temperature: . . . 840.2 F°
Explosion Limits . . .Lower . . 2.3 volume %
. . .Upper . . 37 volume %
Fire Extinguishing Media:
Use flooding quantities of water as spray. Use water spray, dry
chemical, carbon dioxide, or alcohol-resistant foam.
Fire Fighting Procedure:
Extremely flammable liquid and vapor. Vapor may cause flash fire.
Hazardous polymerization may occur under fire conditions.
Evacuate area and fight fire from a safe distance. Wear self-contained
breathing apparatus in pressure-demand, MSHA/NIOSH approved or
equivalent, full protective gear. Vapors may form an explosive mixture
with air. Use water spray to keep fire-exposed containers cool. Fire or
excessive heat may cause violent rupture of the container due to bulk
polymerization. Closed containers may rupture violently when heated.
Vapors are heavier than air and may travel to a source of ignition and
flash back. Vapors may collect in low or confined areas.
Spill Response:
General Information: Wear suitable protective equipment listed under
exposure/personal protection, including self contained breathing
apparatus.
Spills/Leaks: Avoid runoff into storm sewers and ditches, which lead to
waterways. Avoid all sources of ignition. Provide ventilation. Absorb
spill with an absorbent, non-combustible material such as earth or sand
(not clay-based or vermiculite) and place in suitable container for proper
disposal, using a spark-proof tool. Approach spill from upwind. Use water
spray to cool and disburse vapors, protect personnel, and dilute spills to
form nonflammable mixtures. Do not use clay-based absorbents. Ground
and bond containers and handling equipment.
Handling: Use only in a well-ventilated area or with respiratory protection. Do not breathe vapor. Do not use air pressure to empty containers. Refrigerate to 0°C before opening. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. Take precautionary measures against static discharges. Ground and bond containers when transferring material. Use spark-proof tools and explosion proof equipment. Avoid contact with heat, sparks and flame. Empty containers may contain residue - do not pressurize, or expose empty containers to heat, sparks or open flames. Keep tightly closed. Avoid contact with eyes, skin and clothing. Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid ingestion or inhalation. Storage: Keep away from sources of ignition. Keep away from heat, sparks, and flame. Store in a tightly closed container. Store in a flammables area, away from incompatible materials. Store in cool, dry, well ventilated area. Storage under a nitrogen blanket has been recommended. Should not be exposed to temperatures above 122 °F. Do not store product contaminated with water due to potential for hazardous reaction. Propylene oxide reacts with water to produce propylene glycol, dipropylene glycol, tripropylene glycol and higher molecular weight polyglycols.
An eyewash facility and a safety shower should be available. Use process
enclosure, local exhaust ventilation, or other engineering controls to control
airborne levels below recommended exposure limits. Use explosion-proof ventilation
equipment.
Airborne Exposure Limits:
Chemical Name ACGIH NIOSH OSHA - Final PEL
Propylene oxide 2 ppm TWA 400 ppm TWA 100 ppm TWA
240 mg/m3 TWA
OSHA Vacated PELS:
Propylene oxide: 20 ppm TWA; 50mg/m3 = TWA
Personal Protective Equipment:
Eyes: Wear chemical safety goggles and face shield as described by OSHA's eye and
face protection regulations in 29 CFR 1910.134 and ANSI Z88.2 requirements or the
European Standard EN149.
Skin: Wear appropriate protective gloves to prevent skin exposure.
Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators: Follow the OSHA respirator regulations found in 29CFR 1910.134 and
ANSI Z88.2 requirements or the European Standard EN149 whenever workplace
conditions warrant a respirator’s use.
Boiling Point.(760mm Hg). 34°C Formula Weight..(g/mol).. 58.04 pH (Liquids Only)........ not available Melting Point............ -112°C Vapor Pressure.(mm Hg)... 442 @20°C Vapor Density/Air is 1... 2.0 Solubility In Water...... soluble Appearance and Color..... colorless liquid Specific Gravity(H2O=1): 0.83 Evaporation Rate not available Odor..................... sweetish ether-like odor Molecular Formula........ CH3CHCH2O
Stable: Stable under normal temperatures and pressures.
Hazardous Polymerization: Will occur. May polymerize violently, especially
in the presence of aqueous sodium hydroxide, chlorine, ammonia, strong
oxidants, and acids.
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
irritating and toxic fumes and gases
Conditions to avoid: Ignition sources, temperatures above 50°C or 122°F,
confined spaces
Materials to avoid: Strong oxidizing agents, acids, bases, amines, ammonia,
copper, copper alloys, iron, peroxides, catalytic metals, aluminum chloride,
ethylene oxide + polyhydric alcohol, anhydrous metal chloride, clay-based
absorbents, vermiculite
RTECS #: CAS# 75-56-9: TZ2975000
Toxicity data: CAS# 75-56-9
Draize test, Rabbit, eye: 20mg Severe
Draize test, Rabbit, eye: 20mg/24H Moderate
Draize test, Rabbit, skin: 50mg/6M Severe
Inhalation,Mouse LC50: 1740 ppm/4H
Inhalation, rat LC50: 4000 ppm/8H
Oral, Mouse LD50: 440 mg/kg
Skin, Rabbit LD50: 1500µl/kg
Oral, rat LD50: 380 mg/kg
Carginogenicity:
CAS# 75-56-9:
ACGIH: A3- Confirmed animal carcinogen with unknown
relevance to humans
California: Carcinogen, initial date 10/1/88
NIOSH: Potential occupational carcinogen
NTP: Suspect carcinogen
OSHA: Possible select carcinogen
IARC: Group 2B carcinogen
Edidemiology: Case reports of eczema and skin sensitization from exposure
to propylene oxide have appeared in published literature.
Teratogenicity: Birth defects are unlikely. Exposures having no effects on
the mother should have no effects on the fetus. Did not cause birth
defects in animals.
Reproductive effect:
Did not interfere with reproduction in animal studies.
Neurotoxicity: Rats exposed to 1500 ppm for 6 hours a day, 5 days a week,
for 7 weeks developed ataxia in the hind legs with axonal degeneration of
the myelinated fibers in the hindleg nerve and fasciculus gracilis.
Mutagenicity:
In vitro mutagenicity studies were positive. Animal mutagenicity studies
were predominantly negative. In a fruit fly assay with exposures of 645
ppm, mutagenic effects were seen.
Ecotoxicity:
Fish:
Goldfish: LC50 170 mg/L; 24h
Bluegill/Sunfish TLM 215 mg/l; 96h
Environmental:
Terrestrial: If released to the soil, propylene oxide is expected to be
susceptible to leaching and chemical hydrolysis in moist soils. It is
expected to evaporate relatively rapidly from dry soil surfaces. If
released to water, propylene oxide will hydrolyze. Volatilization of
propylene oxide from the aquatic environment may be an important
transport mechanism.
Atmospheric: If released to the atmosphere, will react in the vapor phase
with photochemically produced hydroxyl radicals with an estimated half-life
of approximately 30 days. Removal via rainfall may occur. Bio-concentration
in aquatic organisms, adsorption to sediment, or reaction with
photochemically produced hydroxyl radicals in water are not expected to be
environmentally important processes.
Consult state and local hazardous waste regulations to ensure complete and accurate classification. US EPA guidelines for hazard classification determination are listed in 40 CFR Parts 261.3. RCRA P-Series: Not listed RCRA U-Series: Not listed
US DOT CAN.TDG
Shipping Name Propylene Oxide Propylene Oxide
Hazard Class 3 3
UN Number UN1280 UN1280
Packing Group I I
Flash Point -37°C
