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Date Effective........... March 30, 2006
(most recent revision)
Chemical Name/Synonyms... Chloroform
Emergencies
Contacting CHEMTREC:
24 Hour Emergency Use Only #'s...
Worldwide phone: 1-(703)-527-3887
Worldwide FAX: 1-(703)-741-6090
Toll-free phone: 1-(800)-424-9300 USA only
Product or Trade Name.... SPI # 02520-AA and 02520-AB Chloroform
Synonyms................. Methenyl chloride, Refrigerant 20,
trichloroform, trichloromethane,
methane trichloride
| Hazardous
Material Information System USA | Health | 2 | National Fire Protection Association USA |  |
| Fire Hazard | 0 | |||
| Reactivity | 0 | |||
| Personal Protection |
Component Name CAS # Percent EINECS/ELINCS Chloroform 67-66-3 >99 200-663-8
Emergency overview: Appearance: clear, colorless.Warning!
Light sensitive. Cancer suspect agent. May cause central nervous system depression. Aspiration hazard. May cause eye and skin irritation. May cause respiratory and digestive tract irritation. May cause cardiac disturbances. May cause reproductive and fetal effects. May cause cancer based on animal studies. Target Organs: Kidneys, heart, central nervous system, liver, gastrointestinal system, excretory system. Potential Health Effects Eye: Contact with liquid or vapor causes severe burns and possible irreversible eye damage. Vapors may cause eye irritation. Contact produces irritation, tearing, and burning pain. May cause conjunctivitis. Causes redness and pain. Skin: Causes irritation with burning pain, itching, and redness. Ingestion: Aspiration hazard. May cause central nervous system depression, kidney damage, and liver damage. May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause cardiac disturbances. Aspiration of material into the lungs may cause chemical pneumonitis, which may be fatal. Inhalation: Inhalation of high concentrations may cause central nervous system effects characterized by headache, dizziness, unconsciousness and coma. Causes respiratory tract irritation. May cause liver and kidney damage. May cause cardiac sensitization and possible failure. Chronic: Over-exposure may cause delayed kidney injury. Possible cancer hazard based on tests with laboratory animals. Chronic ingestion may cause liver damage. Prolonged or repeated skin contact may cause dermatitis. Prolonged or repeated exposure may cause adverse reproductive effects. May cause fetal effects. Chronic exposure has been associated with an increased incidence of kidney, liver, rectal, bladder, colon, brain, and lymph node cancer. Toxicity may be increased by exposure to alcohol, steroids, and ketones.
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower lids. Get medical aid immediately. Do not allow victim to rub or keep eyes closed. Skin: Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Discard contaminated clothing in a manner which limits further exposure. Ingestion: Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Possible aspiration hazard. Get medical aid immediately. Inhalation: Get medical aid immediately. Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen. Notes to Physician: Causes cardiac sensitization to endogenous catecholamines which may lead to cardiac arrhythmias. Do not use adrenaline-derivative agents such as epinephrine or pseudoepinephrine.
General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Substance is noncombustible. Extinguishing Media: In case of fire, use water fog, dry chemical, carbon dioxide, or regular foam. Autoignition Temperature: Not available. Flash Point: Not available. Explosion Limits: Lower: Not available. Upper: Not available.
General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container.
Handling: Wash thoroughly after handling. Use only in a well ventilated area. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation. Storage: Do not store in direct sunlight. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Engineering Controls:
Use adequate general or local exhaust ventilation to keep airborne
concentrations below the permissible exposure limits.
Exposure Limits:
Chemical Name ACGIH NIOSH OSHA - Final PELs
Chloroform 10 ppm; 49 mg/m3 500 ppm IDHL 500 ppm Ceiling
240 mg/m3 Ceiling
OSHA Vacated PELs:
Chloroform: 2 ppm TWA; 9.78 mg/m3 TWA
Personal Protective Equipment
Eyes:
Wear appropriate protective eyeglasses or chemical safety goggles as
described by OSHA's eye and face protection regulations in 29 CFR
1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29CFR 1910.134
or European Standard EN 149. Always use a NIOSH or European
Standard EN 149 approved respirator when necessary.
Physical State: Liquid Appearance: Clear, colorless Odor: Sweet. pH: Not available. Vapor Pressure: 160 mm Hg Vapor Density: 4.12 (Air=1) Evaporation Rate: Not known Viscosity: 0.58 @ 20 °C (68°F) Boiling Point: 61° C/142° F Freezing/Melting Point: -63°C (-81.4°F) Decomposition Temperature: Not available. Solubility in water: Slightly soluble. Specific Gravity/Density: 1.50 g/cm3 Molecular Formula: CHCl3 pH: Not applicable
Chemical Stability: Stable at room temperature in closed containers under normal storage and handling conditions. Conditions to Avoid: High temperatures, light. Incompatibility with Other Materials: Acetone, alkalis, aluminum, disilane, lithium, magnesium, dinitrogen dioxide, nitrogen tetroxide, perchloric acid, phosphorus pentoxide, potassium, potassium hydroxide, methyl alcohol, potassium tert-butoxide, sodium, sodium hydroxide, sodium methylate, sodium-potassium alloy, triisopropylphosphine, calcium hydroxide, fluorine, and any strong oxidizers. Hazardous Decomposition of Products: Hydrogen chloride, carbon monoxide, carbon dioxide, chlorine, phosgene gas. Hazardous Polymerization: Has not been reported.
CAS #: 67-66-3 LD50/LC50 Information: CAS #: 67-66-3 Inhalation, rat: LC50=47702 mg/m3/4H Oral, mouse: LD50 = 36 mg/kg Oral, rat: LD50 = 908 mg/kg Skin, rabbit: LD50 = >20 gm/kg Carcinogenicity: CAS #67-66-3: ACGIH: A3 - Animal Carcinogen California: carcinogen - initial date 10/1/87 NIOSH: occupational carcinogen NTP: Suspect carcinogen OSHA: Possible Select carcinogen IARC: Group 2B carcinogen Epidemiology: Please see IARC volume 20 for a detailed discussion. Teratogenicity: Effects on newborn: Biochemical and Metabolic, Growth statistics (reduced weight gain), Oral-mouse, TDLo=2177 mg/kg (male 3W pre) Embryo or Fetus: Death, Ihl-rat, TCLo=20100 ug/m3/1H (female 7-14D post); Stunted fetus, Oral-rat, TDLo=1260 mg/kg (6-15D preg) Developmental abnormalities: Craniofacial, Ihl-mouse, TCLo=100 ppm/7H (female 6-15D post); Musculoskeletal, Oral-rat, TDLo=1260 mg/kg (6-15D preg) Reproductive Effects: Fertility: Female index, Ihl-mouse, TCLo=100 ppm/7H (female 1-7D post) Neurotoxicity: No information available. Mutagenicity: DNA Damage: Mammal lymphocyte, 1 mmol/L Sister Chromatid Exchange: Human lymphocyte, 10 mmol/L Other Studies: None known.
Exotoxicity: Rainbow trout, LC50=2030 ug/L Bluegill, LC50=100,000 ug/L/96H Large mouth bass, LC50=51 ppm/96H Fish: 10 mg/l Fish-toxicity: LC50: 162 mg/l Pseudomonas putida: 125 mg/l Scenedesmus quadricanda: 1100 mg/l Microcystis aeruginosa: 185 mg/l Entosiphonsulcatum: 6560 mg/l Environmental Fate: If released to land, most evaporates rapidly while some leaches to ground-water. If released to water, substance evaporates rapidly. Bioaccumulation: Substance photodegrades with T1/2 of 80 days.
Dispose of in a manner consistent with federal, state, and local regulations. RCRA D-Series Maximum Concentration of Contaminants: CAS# 67-66-3: waste number D022; regulatory level = 6.0 mg/L. RCRA D-Series Chronic Toxicity References Levels: CAS# 67-66-3: chronic toxicity reference level = 0.06 mg/L. RCRA F-Series: None listed. RCRA P-Series: None listed. RCRA U-Series: CAS# 67-66-3: waste numberU044.
US DOT Hazard Class: Shipping Name: Chloroform Hazard Class: 6.1 UN Number: UN1888 Packing Group: III IATA (for international shipments) Shipping Name: Chloroform Hazard Class: 6.1 UN Number: UN1888 Packing Group: III RID/ADR Shipping Name: Chloroform Hazard Class: 6.1 (15C) UN Number: UN1888 Packing Group: N/A IMO Shipping Name: Chloroform Hazard Class: 6.1 UN Number: UN1888 Packing Group: III Canada TDG Shipping Name: Chloroform Hazard Class: 6.1 (9.2) UN Number: UN1888 Packing Group: II
US FEDERAL
TSCA CAS# 67-66-3 is listed on the TSCA inventory. Health & Safety Reporting List CAS# 67-66-3: Effective Date: June 1, 1987; Sunset Date: June 1, 1997 Chemical Test Rules None of the chemicals in this product are under a Chemical Test Rule. Section 12b None of the chemicals are listed under TSCA Section 12b. TSCA Significant New Use Rule None of the chemicals in this material have a SNUR under TSCA. SARA Section 302 (RQ) CAS #67-66-3: final RQ = 10 pounds (4.54 kg) Section 302 (TPQ) CAS# 67-66-3: TPQ = 10,000 pounds; RQ = 10 pounds (does not meet toxicity criteria but because of high production volume and recognized toxicity is considered a chemical of concern) SARA Codes CAS #67-66-3: acute, chronic. Section 313 This material contains Chloroform (CAS# 67-66-3, 99%),which is subject to the reporting requirements of Section 313 of SARA Title III and 40 CFR Part 373. Clean Air Act: CAS #67-66-3 is listed as a hazardous air pollutant (HAP). This material does not contain any Class 1 Ozone depletors. This material does not contain any Class 2 Ozone depletors. Clean Water Act: CAS #67-66-3 is listed as a Hazardous Substance under the CWA. CAS #67-66-3 is listed as a Priority Pollutant under the Clean Water Act. CAS #67-66-3 is listed as a Toxic Pollutant under the Clean Water Act. OSHA: None of the chemicals in this product are considered highly hazardous by OSHA. STATE BY STATE IN THE USA: CAS #67-66-3 can be found on the following state right to know lists: California, New Jersey, Florida, Pennsylvania, Minnesota, Massachusetts. The following statement(s) is(are) made in order to comply with the California Safe Drinking Water Act: WARNING: This product contains Chloroform, a chemical known to the state of California to cause cancer. California No Significant Risk Level: CAS #67-66-3: ingestion: no significant risk level = 20 ug/day; inhalation: no significant risk level = 40 ug/day European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: XN Risk Phrases: R 22 Harmful if swallowed. R 38 Irritating to skin. R 40 Possible risks of irreversible effects. R 48/20/22 Harmful: danger of serious damage to health by prolonged exposure through inhalation and if swallowed. Safety Phrases: S 36/37 Wear suitable protective clothing and gloves. WGK (Water Danger/Protection) CAS #67-66-3: 3 Canada CAS #67-66-3 is listed on Canada's DSL/NDSL List. This product does not have a WHMIS classification. CAS #67-66-3 is not listed on Canada's Ingredient Disclosure List. Exposure Limits CAS #67-66-3: OEL-ARAB Republic of Egypt: TWA 10 ppm (50 mg/m3) OEL- AUSTRALIA: TWA 10 ppm (50 mg/m3); Carcinogen OEL-AUSTRIA: TWA 10 ppm (50 mg/m3) OEL-BELGIUM: TWA 10 ppm (49 mg/m3); Carcinogen JAN9 OEL-CZECHO SLOVAKIA: TWA 10 mg/m3; STEL 20 mg/m3 OEL-DENMARK: TWA 2 ppm (10 mg/m3); Carcinogen OEL-FINLAND: TWA 10 ppm (50 mg/m3); STEL 20 ppm; Skin; CAR OE L-FRANCE: TWA 5 ppm (25 mg/m3); STEL 50 ppm (250 mg/m3); CAR OEL-GERMANY: TWA 10 ppm (50 mg/m3); Carcinogen JAN9 OEL-HUNGARY: STEL 10 mg/m3 OEL - INDIA: TWA 10 ppm (50 mg/m3); Carcinogen OEL-JAPAN:TWA 50 ppm (240 mg/m3); Carcinogen OEL-THE NETHERLANDS: TWA 10 ppm (50 mg/m3) OEL-THE PHI LIPPINES: TWA 50 ppm (240 mg/m3) OEL-POLAND: TWA 50 mg/m3 OEL-RUSSIA: T WA 50 ppm OEL-SWEDEN: TWA 2 ppm (10 mg/m3); STEL 5 ppm (25 mg/m3); CAR OEL-SWITZERLAND: TWA 10 ppm (50 mg/m3); STEL 20 ppm (100 mg/m3) OEL-THA ILAND: TWA 50 ppm (240 mg/m3) OEL-TURKEY: TWA 50 ppm (240 mg/m3) OEL-U NITED KINGDOM: TWA 10 ppm (50 mg/m3); STEL 50 ppm (225 mg/m3) OEL IN BU LGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, S INGAPORE, VIETNAM check ACGI TLV California Prop. 65: Proposition 65 requires manufacturers or distributors of consumer products into the State of California to provide a warning statement if the product contains ingredients for which the State has found to cause cancer, birth defects or other reproductive harm. If this product contains an ingredient listed by the State of California to cause cancer or reproductive toxicity, it will be listed below: Chloroform CAS #67-66-3
Disclaimer of Liability: Caution! Do not use SPI Supplies products or materials in applications involving implantation within the body; direct or indirect contact with the blood pathway; contact with bone, tissue, tissue fluid, or blood; or prolonged contact with mucous membranes. Products offered by SPI Supplies are not designed or manufactured for use in implantation in the human body or in contact with internal body fluids or tissues. SPI Supplies will not provide to customers making devices for such applications any notice, certification, or information necessary for such medical device use required by US FDA (Food and Drug Administration) regulation or any other statute. SPI Supplies and Structure Probe, Inc. make no representation, promise, express warranty or implied warranty concerning the suitability of these materials for use in implantation in the human body or in contact with internal body tissues of fluids.
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