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Material Safety Data Sheet

SPI #02464-CA and 02464-MB SPI-Chem™ 1% Formvar® in Chloroform Solution

Section 1: Identification

Date Effective...........  January 8, 2009
                           (most recent revision)

Chemical Name/Synonyms... 1% Formvar in Chloroform Solution; 
                          1% Polyvinyl formal in Chloroform Solution

Contacting CHEMTREC:

24 Hour Emergency Use Only #'s... 
Worldwide phone: 1-(703)-527-3887
Worldwide FAX:   1-(703)-741-6090 
Toll-free phone: 1-(800)-424-9300 USA only

Product or Trade Name....  SPI # 02464-CA and 02464-MB 1% 
                           Formvar in Chloroform solution

Hazardous Material
Information System
Health 2 National Fire
Protection Association
Fire Hazard 0
Reactivity 0
Personal Protection
NFPA Rating: Health=2, Flammability=0, Reactivity=0

Section 2 Composition

Component Name            CAS #          Percent       EINECS/ELINCS
Chloroform               67-66-3           99           200-663-8
Formvar			63450-15-7	    1		N/A

Section 3: Hazard Identification

Emergency overview:

Appearance:  clear, colorless. 

Light sensitive.  Cancer suspect agent.  May cause central nervous
system depression. 

Aspiration hazard.
May cause eye and skin irritation. 
May cause respiratory and digestive tract irritation. 
May cause cardiac disturbances. 
May  cause reproductive and fetal effects. 
May cause cancer based on animal studies.

Target Organs:  
Kidneys, heart, central nervous system, liver, gastrointestinal system, 
excretory system.

Potential Health Effects

Contact with liquid or vapor causes severe burns and possible
irreversible eye damage.  Vapors may cause eye irritation.  Contact
produces irritation, tearing, and burning pain.  May cause conjunctivitis.
Causes redness and pain. 

Causes irritation with burning pain, itching, and redness. 

Aspiration hazard. May cause central nervous system depression, kidney
damage, and liver damage.  May cause gastrointestinal irritation with
nausea, vomiting and diarrhea.  May cause cardiac disturbances.
Aspiration of material into the lungs may cause chemical pneumonitis,
which may be fatal. 

Inhalation of high concentrations may cause central nervous system
effects characterized by headache, dizziness, unconsciousness and coma.
Causes respiratory tract irritation.  May cause liver and kidney damage.
May cause cardiac sensitization and possible failure. 

Over-exposure may cause delayed kidney injury.  Possible cancer hazard
based on tests with laboratory animals.  Chronic ingestion may cause
liver damage.  Prolonged or repeated skin contact may cause dermatitis.
Prolonged or repeated exposure may cause adverse reproductive effects.
May cause fetal effects.  Chronic exposure has been associated with an
increased incidence of kidney, liver, rectal, bladder, colon, brain, and
lymph node cancer.  Toxicity may be increased by exposure to alcohol,
steroids, and ketones.

Section 4: First Aid Measures

Immediately flush eyes with plenty of water for at least 15 minutes,
occasionally lifting the upper and lower lids.  Get medical aid immediately.
Do not allow victim to rub or keep eyes closed.

Get medical aid immediately.  Immediately flush skin with plenty of soap
and water for at least 15 minutes while removing contaminated clothing and
shoes.  Discard contaminated clothing in a manner which limits further

Do not induce vomiting.  If victim is conscious and alert, give 2-4
cupfuls of milk or water.  Never give anything by mouth to an unconscious
person.  Possible aspiration hazard.  Get medical aid immediately. 

Get medical aid immediately.  Remove from exposure to fresh air immediately.
If breathing is difficult, give oxygen.
Notes to Physician:
Causes cardiac sensitization to endogenous catecholamines which may lead
to cardiac arrhythmias.  Do not use adrenaline-derivative agents such as
epinephrine or pseudoepinephrine.

Section 5: Fire Fighting Measures

General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear.  Substance is noncombustible. 

Extinguishing Media:
In case of fire, use water fog, dry chemical, carbon dioxide,
or regular foam.
Autoignition Temperature:
Not available. 

Flash Point:
Not available. 

Explosion Limits:
   Lower:  Not available. 
   Upper:  Not available.

Section 6: Accidental Release Measures

General Information:
Ventilate area of leak or spill.  Remove all sources of ignition.  Wear appropriate 
protective equipment as indicated in section 8.

Contain and recover liquid if possible. Absorb spill with inert material such as 
vermiculite, sand or earth. Scoop up with nonsparking tool and place in suitable 
container for disposal.  Avoid runoff into storm sewers and ditches which lead 
to waterways.  Wash spill site after pickup is complete.

Section 7: Handling and Storage

Wash thoroughly after handling.  Use only in a well ventilated area.  Avoid
contact with eyes, skin, and clothing.  Avoid ingestion and inhalation. 

Do not store in direct sunlight.  Store in a tightly closed container.
Store in a cool, dry, well-ventilated area away from incompatible substances.

Section 8: Exposure Controls and Personal Protection

Engineering Controls:

Use adequate general or local exhaust ventilation to keep airborne
concentrations below the permissible exposure limits.

Exposure Limits:

Chemical Name        ACGIH              NIOSH         OSHA - Final PELs
Chloroform      10 ppm; 49 mg/m3    500 ppm IDHL    C 50 ppm; C 240 mg/m3                  

OSHA Vacated PELs:
Chloroform:  2 ppm TWA; 9.78 mg/m3 TWA

Personal Protective Equipment

Wear appropriate protective eyeglasses or chemical safety goggles as
described by OSHA's eye and face protection regulations in 29 CFR
1910.133 or European Standard EN166.

Wear appropriate protective gloves to prevent skin exposure.

Wear appropriate protective clothing to prevent skin exposure.

Follow the OSHA respirator regulations found in 29CFR 1910.134
or European Standard EN 149.  Always use a NIOSH or European
Standard EN 149 approved respirator when necessary.

Section 9: Physical and Chemical Properties

Physical State:  Liquid
Appearance:  Clear, colorless
Odor:  Sweet.
pH:  Not available.
Vapor Pressure:  160 mm Hg
Vapor Density:  4.12 (Air=1)
Evaporation Rate:  11.6 (Butyl acetate =1)
Viscosity:  56.3 CPS @ 20 °C (68°F)
Boiling Point:  62° C/143° F
Freezing/Melting Point:  -64°C (-82°F)
Decomposition Temperature:  Not available.
Solubility in water:  Slightly soluble.
Specific Gravity/Density:  1.48 g/cm3
Molecular Formula:  N/A
pH:  N/A

Section 10: Stability and Reactivity

Chemical Stability:
Stable at room temperature in closed containers under normal storage
and handling conditions.

Conditions to Avoid:
High temperatures, light.

Incompatibility with Other Materials:
Acetone, alkalis, aluminum, disilane, lithium, magnesium, dinitrogen
dioxide, nitrogen tetroxide, perchloric acid, phosphorus pentoxide,
potassium, potassium hydroxide, methyl alcohol, potassium tert-butoxide,
sodium, sodium hydroxide, sodium methylate, sodium-potassium alloy,
triisopropylphosphine, calcium hydroxide, fluorine, and any strong oxidizers.

Hazardous Decomposition of Products:
Hydrogen chloride, carbon monoxide, carbon dioxide, chlorine, phosgene gas.

Hazardous Polymerization:  
Has not been reported.

Section 11: Toxicological Information

CAS #:  67-66-3 

LD50/LC50 Information:
CAS #:  67-66-3
Inhalation, rat:  LC50=47702 mg/m3/4H
Oral, mouse:  LD50 = 36 mg/kg
Oral, rat:  LD50 = 908 mg/kg
Skin, rabbit:  LD50 = >20 gm/kg

CAS #67-66-3: 
ACGIH:  A3 - Animal Carcinogen 
California:  carcinogen - initial date 10/1/87 
NIOSH:  occupational carcinogen 
NTP:  Suspect carcinogen 
OSHA:  Possible Select carcinogen 

IARC:  Group 2B carcinogen 
Epidemiology:  Please see IARC volume 20 for a detailed discussion. 


Effects on newborn:  Biochemical and Metabolic, Growth statistics
(reduced weight gain), Oral-mouse, TDLo=2177 mg/kg
(male 3W pre) Embryo or Fetus:  Death, Ihl-rat, TCLo=20100 ug/m3/1H
(female 7-14D post); Stunted fetus, Oral-rat, TDLo=1260 mg/kg (6-15D preg)

Developmental abnormalities:  Craniofacial, Ihl-mouse, TCLo=100 ppm/7H
(female 6-15D post); Musculoskeletal, Oral-rat, TDLo=1260 mg/kg (6-15D preg)

Reproductive Effects:
Fertility:  Female index, Ihl-mouse, TCLo=100 ppm/7H
(female 1-7D post) 

Neurotoxicity:  No information available. 

DNA Damage:  Mammal lymphocyte, 1 mmol/L Sister
Chromatid Exchange:  Human lymphocyte, 10 mmol/L

Other Studies:  None known.

CAS#:  63450-15-7
Not considered to be toxic to humans or animals

Section 12: Ecological Information

CAS#: 67-66-3
Rainbow trout, LC50=2030 ug/L
Bluegill, LC50=100,000 ug/L/96H
Large mouth bass, LC50=51 ppm/96H
Fish: 10 mg/l

LC50:  162 mg/l
Pseudomonas putida:  125 mg/l
Scenedesmus quadricanda:  1100 mg/l
Microcystis aeruginosa:  185 mg/l
Entosiphonsulcatum:  6560 mg/l 

Environmental Fate:
If released to land, most evaporates rapidly while some leaches to
ground-water.  If released to water, substance evaporates rapidly. 

Substance photodegrades with T1/2 of 80 days.

Section 13: Disposal Considerations

Dispose of in a manner consistent with federal, state, and local regulations.

RCRA D-Series Maximum Concentration of Contaminants:
CAS# 67-66-3:  waste number D022; regulatory level = 6.0 mg/L.

RCRA D-Series Chronic Toxicity References Levels:
CAS# 67-66-3:  chronic toxicity reference level = 0.06 mg/L.
RCRA F-Series:  None listed.
RCRA P-Series:  None listed.

RCRA U-Series:  CAS# 67-66-3:  waste numberU044.

Section 14: Transport Information


US DOT Hazard Class:
Shipping Name:  Chloroform
Hazard Class:  6.1
UN Number:  UN1888
Packing Group:  III

IATA (for international shipments):
Shipping Name:  Chloroform
Hazard Class:  6.1
UN Number:  UN1888
Packing Group:  III

Shipping Name:  Chloroform
Hazard Class:  6.1  (15C)
UN Number:  UN1888
Packing Group:  N/A

Shipping Name:  Chloroform
Hazard Class:  6.1
UN Number:  UN1888
Packing Group:  III  

Canada TDG
Shipping Name:  Chloroform
Hazard Class:  6.1  (9.2)
UN Number:  UN1888
Packing Group:  II

Section 15: Regulatory Information


CAS# 67-66-3 is listed on the TSCA inventory. 
CAS# 63450-15-7 is listed on the TSCA inventory.

Health & Safety Reporting List
CAS# 67-66-3:  Effective Date:  June 1, 1987; Sunset Date:  June 1, 1997 

Chemical Test Rules
None of the chemicals in this product are under a Chemical Test Rule. 

Section 12b
None of the chemicals are listed under TSCA Section 12b. 

TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA. 


Section 302 (RQ)

CAS #67-66-3:  final RQ = 10 pounds (4.54 kg) 

Section 302 (TPQ)
CAS# 67-66-3:  TPQ = 10,000 pounds; RQ = 10 pounds (does not meet toxicity
criteria but because of high production volume and recognized toxicity is
considered a chemical of concern) 

SARA Codes
CAS #67-66-3:  acute, chronic. 

Section 313
This material contains Chloroform (CAS# 67-66-3, 99%),which is subject to
the reporting requirements of Section 313 of SARA Title III and 40 CFR
Part 373. 

Clean Air Act:
CAS #67-66-3 is listed as a hazardous air pollutant (HAP).  This material
does not contain any Class 1 Ozone depletors.  This material does not
contain any Class 2 Ozone depletors. 

Clean Water Act:
CAS #67-66-3 is listed as a Hazardous Substance under the CWA.
CAS #67-66-3 is listed as a Priority Pollutant under the Clean Water Act.
CAS #67-66-3 is listed as a Toxic Pollutant under the Clean Water Act. 


None of the chemicals in this product are considered highly hazardous
by OSHA. 

CAS #67-66-3 can be found on the following state right to know lists:
California, New Jersey, Florida, Pennsylvania, Minnesota, Massachusetts.
The following statement(s) is(are) made in order to comply with the
California Safe Drinking Water Act:

WARNING:  This product contains Chloroform, a chemical known to the
state of California to cause cancer.

California No Significant Risk Level:
CAS #67-66-3:
ingestion:   no significant risk level = 20 ug/day;
inhalation:  no significant risk level = 40 ug/day 

European/International Regulations
European Labeling in Accordance with EC Directives

Hazard Symbols:  XN
Risk Phrases:
R 22 Harmful if swallowed.
R 38 Irritating to skin.
R 40 Possible risks of irreversible effects.
R 48/20/22 Harmful:  danger of serious damage to health by prolonged
exposure through inhalation and if swallowed. 

Safety Phrases:
S 36/37 Wear suitable protective clothing and gloves. 

WGK (Water Danger/Protection)
CAS #67-66-3:  3

CAS #67-66-3 is listed on Canada's DSL/NDSL List.
This product does not have a WHMIS classification.
CAS #67-66-3 is not listed on Canada's Ingredient Disclosure List.

Exposure Limits

CAS #67-66-3:  OEL-ARAB Republic of Egypt:  TWA 10 ppm (50 mg/m3)
OEL- AUSTRALIA:  TWA 10 ppm (50 mg/m3); Carcinogen OEL-AUSTRIA:  TWA
10 ppm (50 mg/m3) OEL-BELGIUM:  TWA 10 ppm (49 mg/m3); Carcinogen JAN9
ppm (10 mg/m3); Carcinogen OEL-FINLAND:  TWA 10 ppm (50 mg/m3); STEL
20 ppm; Skin; CAR OE L-FRANCE:  TWA 5 ppm (25 mg/m3); STEL 50 ppm
(250 mg/m3); CAR OEL-GERMANY:  TWA 10 ppm (50 mg/m3); Carcinogen
JAN9 OEL-HUNGARY:  STEL 10 mg/m3 OEL - INDIA:  TWA 10 ppm (50 mg/m3);
Carcinogen OEL-JAPAN:TWA 50 ppm (240 mg/m3); Carcinogen OEL-THE NETHERLANDS:
TWA 10 ppm (50 mg/m3) OEL-THE PHI LIPPINES:  TWA 50 ppm (240 mg/m3)
OEL-POLAND:  TWA 50 mg/m3 OEL-RUSSIA:  T WA 50 ppm OEL-SWEDEN:  TWA 2 ppm
(10 mg/m3); STEL 5 ppm (25 mg/m3); CAR  OEL-SWITZERLAND:  TWA 10 ppm
(50 mg/m3); STEL 20 ppm (100 mg/m3) OEL-THA ILAND:  TWA 50 ppm (240 mg/m3)
OEL-TURKEY:  TWA 50 ppm (240 mg/m3) OEL-U NITED KINGDOM:  TWA 10 ppm
(50 mg/m3); STEL 50 ppm (225 mg/m3) OEL IN BU LGARIA, COLOMBIA, JORDAN,
check ACGI TLV 

California Prop. 65:

  Proposition 65 requires manufacturers or distributors of consumer
  products into the State of California to provide a warning statement
  if the product contains ingredients for which the State has found to
  cause cancer, birth defects or other reproductive harm.  If this product
  contains an ingredient listed by the State of California to cause cancer
  or reproductive toxicity, it will be listed below:

  Chloroform      CAS #67-66-3

Section 16: Other Information

Disclaimer of Liability:

Caution!  Do not use SPI Supplies products or materials in applications
involving implantation within the body; direct or indirect contact with
the blood pathway; contact with bone, tissue, tissue fluid, or blood; or
prolonged contact with mucous membranes.  Products offered by SPI Supplies
are not designed or manufactured for use in implantation in the human body
or in contact with internal body fluids or tissues.  SPI Supplies will not
provide to customers making devices for such applications any notice,
certification, or information necessary for such medical device use required
by US FDA (Food and Drug Administration) regulation or any other statute.
SPI Supplies and Structure Probe, Inc. make no representation, promise,
express warranty or implied warranty concerning the suitability of these
materials for use in implantation in the human body or in contact with
internal body tissues of fluids.


The information and recommendations set forth above are taken from sources believed to be accurate as of the date hereof, however SPI Supplies and Structure Probe, Inc. make no warranty with respect to the accuracy of the information or the suitability of the recommendations, and assume no liability to any user thereof. The information contained in this sheet does not constitute a hazard assessment and should not be used in place of the user's own assessment of work place risks as required by other health and safety legislation. Be aware of the Structure Probe, Inc. Copyright Policy. Structure Probe, Inc. grants a nonexclusive license to make unlimited copies of this safety sheet for internal use only. Quite obviously, this information would pertain only to this material when purchased from SPI Supplies as product from other sources, with other ingredients and impurity levels could have substantially different properties.

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