|
|
Date Effective........... February 17, 2007
(most recent revision)
Chemical Name/Synonyms... Polyvinyl formal
Chemical family.......... Polyvinyl formal
Emergencies
Contacting CHEMTREC:
24 Hour Emergency Use Only #'s......
Worldwide phone: 1-(703)-527-3887
Worldwide FAX: 1-(703)-741-6090
Toll-free phone: 1-(800)-424-9300 USA only
Product or Trade Name.... SPI #02463-MB Formvar®
Resin for Electron Microscopy
CAS #.................... 63450-15-7 99.9+% polyvinyl formal
50-00-0 < 0.1 formaldehyde
Chemical Formula......... Not known
CAS #.................... 63450-15-7 99.9+% polyvinyl formal
50-00-0 < 0.1 formaldehyde
NFPA Rating: Not known
Emergency overview:
This material is not hazardous by OSHA Hazard Communication
Definition
Physical Health Hazards:
None known.
Physical state: Solid
Color: White to straw colored, free flowing powder
Odor: Slightly pungent
Odor threshold: No data available
Potential Health Effects:
Routes of exposure
Eye, ingestion, skin contact
Signs and Symptoms of Acute Exposure:
Not known. Animals subjected to long term exposure to polyvinyl
alcohol under the skin showed no increase in tumor formation where
a powdered form was used. However, an increase in tumors was reported
in similar studies where polyvinyl alcohol sponges were implanted
(IARC Monographs 19:351-359). NIOSH registry of toxic effects of
chemical substances reported polyvinyl alcohol as "animal positive"
for carcinogenicity. Although the sponge form of polyvinyl alcohol has
caused fibrosis in humans, the information is not considered relevant to
normal workplace exposure to polyvinyl alcohol resins and therefore,
these resins are not considered to pose a carcinogenic risk to a worker.
Skin contact:
Dermal contact is expected to be the primary route of occupational
exposure to Formvar/Vinylac. Occupational exposure to this material
has not been reported to cause significant adverse health effects.
On the basis of available information, exposure to Formvar resin is
not expected to produce significant adverse human health effects when
recommended protection measures are followed.
Inhalation:
If use of the material results in a "dust" being formed, then such
dust should be contained and inhalation minimized. One way to help
contain such free-flying dust would be to "wet" the dry dust. If
exposure is excessive or chronic, then use NIOSH/MSHA approved
respiratory protection equipment.
Eye contact:
Mechanical irritation is possible, therefore the dust form of the
material should be kept from contacting the eyes.
Ingestion:
Ingestion is unlikely.
Chronic Health Effects Summary:
No known chronic health effects.
Conditions Aggravated by Exposure:
No known conditions are aggravated by this material. However, there
is a dust-explosion potential present with the use of this material,
especially when working with larger (than laboratory) quantities.
Take proper precautions to ensure your own health and safety before
attempting to rescue and providing first aid. These practices include
avoiding all unnecessary exposure and removal of the material from eye,
skin , and clothing. For specific information refer to the Emergency
Overview in Section of this MSDS.
Inhalation:
If symptoms are experienced, move victim to fresh
air, if symptoms persist, obtain medical attention.
Eye Contact:
Wash eyes with clean low-pressure water. If
irritation persists, seek medical advice.
Skin Contact:
If powdered or dust form of the material contacts the skin,
immediately flush the skin with large amounts of water. If
irritation or other symptoms persist, seek medical attention.
Ingestion:
Adverse health effects due to ingestion are not
anticipated. If gastric irritation or discomfort
persists, seek medical advice.
NFPA Rating: Not known
Flammability classification: Not classified.
Flash Point/Method: Not applicable
Auto-Ignition Temperature: Not known
Flammable Limits:
Lower: Not applicable
Upper: Not applicable
Hazardous Combustion/Decomposition Products:
Carbon monoxide, carbon dioxide, formaldehyde, acetic acid,
acrolein (trace) may be formed.
Special Conditions to Avoid:
Dust particles in the atmosphere of this material may be explosive.
Keep away from heat, sparks, flame and all other ignition sources.
Keep containers or bags tightly closed. Clean up all dust
accumulations. Prevent dust accumulations and dust clouds,
possibly using water to "wet" dry dust from forming a cloud.
Note: Processes using spray application or fluidized bed
operation should be in accordance with NFPA 33 "Standard for
Spray Applications Using Flammable and Combustible Materials."
Extinguishing Media:
Water spray or any Class A extinguishing agent.
Fire Fighting Instructions:
Protective Equipment/Clothing: Wear a NIOSH approved positive
pressure self-contained breathing apparatus and firefighter
turnout gear. There could be the evolution of toxic products of
combustion. Firefighting equipment should be fully decontaminated
after use.
Instructions:
Use flooding quantities of water until well after fire is out.
Unusual fire and explosion hazards:
Dust when mixed in sufficient quantities with air creates a
potential for explosive concentrations.
Release response:
Vacuum or otherwise pick up and retain for recycle or disposal.
Do not flush spilled material to the sewer or the environment.
Avoid creating a dust cloud since this could create an a potential
for a dust explosion hazard. Use vacuum equipment designed especially
for handling combustible dust.
Reportable Quantities:
See Section 15: Regulatory information.
Handling: The handling of powder in both loading and unloading operations as well as fabrication may cause dust to be formed, and necessary precautions for personal protection (see Section 8) should be used. As with all finely divided materials, precautions should be taken to avoid inhalation and eye contact. Transfer from storage with a minimum amount of dusting. Ground all transfer, blending, and dust collecting equipment to prevent static sparks in accordance with NFPA 70 "National Electric Code." Remove all ignition sources from material handling, transfer, and processing areas where dust may be present. Local exhaust ventilation should be provided in work areas. Ensure that airborne dust concentrations are controlled within acceptable OSHA dust standards. If material is used in spray or fluidized bed operations, see Section 5 of this MSDS for additional information. Of course for the normal electron microscopy application, minute quantities are being used and the real hazard is not from the resin but from the chloroform solvent. Storage: Keep container dry. Store away from excessive heat, sparks and flame. Avoid creating any dust cloud when handling. Keep container closed to prevent contamination.
Engineering Controls:
If user operations generate dust or fumes, ventilate area to
prevent accumulation.
Personal Protection:
Inhalation: Use appropriate respiratory protection where
atmosphere exceeds recommended limits.
Skin: Protective clothing such as long sleeves or a lab
coat should be worn. When handling heated materials,
also be sure to use heat-resistant gloves, boots and
face protection. Such precautions are of course not
necessary for the use of small quantities such as in
an electron microscope laboratory.
Eye: Always use safety glasses, even for work with small
quantities, such as the making Formvar filmed grids.
Boiling Point/Range: Not applicable
pH: Not applicable
Vapor Pressure: Not applicable
Viscosity: Not applicable
Specific Gravity (Water = 1): 1.23
Water solubility: Insoluble
Solubilities: Chloroform, ethylene dichloride, phenols, some chlorinated
hydrocarbons, alcohol mixtures, and certain aromatic
hydrocarbons.
Octanol/Water Partition Coefficient in Kow: Specific value not known
Melting/Freezing Point: Not applicable, resin not crystalline
Evaporation Rate: Not applicable
Chemical Stability:
The product is stable and does not under go a hazardous
polymerization.
Conditions to Avoid:
Avoid contact with excessive heat, sparks or open flame
or dust accumulation.
Incompatibility with:
None known
Hazardous Products of Deposition:
Carbon dioxide, carbon monoxide, formaldehyde,
acotic acid, acrolein (trace).
Reactions with Air and Water:
Does not react with air, water or other common
materials.
Summary:
Not considered to be toxic to humans or animals
Component:
Polyvinyl formal 99.9+%
Formaldehyde < 0.1%
Skin Effects:
No skin effects are expected from Formvar contact.
Acute Oral Effects:
Animal studies showed no adverse health
effects when performed on polyvinyl alcohol.
Acute Inhalation Effects:
None known
Subchronic Effects:
None known
Chronic Effects/Carcinogenicity:
None expected from Formvar however, formaldehyde is a suspected human
carcinogen by IARC. Note: Formaldehyde is present but in less than 0.
1% levels.
Reproductive/Development Effects:
No reproductive or developmental effects are expected.
Exotoxicity: Exotoxicity is expected to be low based on the low
water solubility of polymers. No other information
is known on this topic.
Environmental Fate: No information found in our selected references.
Bioaccumulation: Not expected to occur.
Formvar/Vinylac is not a "hazardous waste" as that term is defined in the Resource Conservation and Recovery Act (RCRA), 40 DFR 261, "Identification and Listing of Hazardous Waste". Burn in an approved incinerator or dispose of in an approved landfill in accordance with all applicable local, state, and federal laws and regulations. Consult your appropriate regulatory officials for information on such disposal.
Proper Shipping Name: Formvar Resin
Special Hazard Precautions: Causes only slight eye irritation.
DOT Hazard Class: Non-Regulated
UN/NA ID: Not Regulated
Packing Group: Not Applicable
Labels: Not Regulated
Marine Pollutant: Not known, but probably not based on its
insolubility in water.
NAER Guidebook: Not Regulated
DOT Status: Not Regulated
TSCA: This product is listed on the TSCA 8(b) inventory.
If identified components of this product are listed
under the TSCA 12(b) Export Notification Rule, they
will be listed below.
TSCA 12(b) Component Listed under TSCA Section
SARA-Section 313 Emissions Reporting:
Component Reporting Threshold
SARA-Section 311/312:
No components present in this product are subject to the reporting
requirements of this statute.
CERCLA Hazardous Substances and their Reportable Quantities:
Component Reportable Quantity
California Prop. 65:
Proposition 65 requires manufacturers or distributors of consumer
products into the State of California to provide a warning statement
if the product contains ingredients for which the State has found to
cause cancer, birth defects or other reproductive harm. If this product
contains an ingredient listed by the State of California to cause cancer
or reproductive toxicity, it will be listed below:
Disclaimer of Liability:Caution! Do not use SPI Supplies products or materials in applications involving implantation within the body; direct or indirect contact with the blood pathway; contact with bone, tissue, tissue fluid, or blood; or prolonged contact with mucous membranes. Products offered by SPI Supplies are not designed or manufactured for use in implantation in the human body or in contact with internal body fluids or tissues. SPI Supplies will not provide to customers making devices for such applications any notice, certification, or information necessary for such medical device use required by US FDA (Food and Drug Administration) regulation or any other statute. SPI Supplies and Structure Probe, Inc. make no representation, promise, express warranty or implied warranty concerning the suitability of these materials for use in implantation in the human body or in contact with internal body tissues of fluids.
To Ask a Question or Make a Comment
To Place an Order or Request a Quote
