SPI-Mark™ Colloidal Gold Reagents
Osmium coating of surface tagged cells
The use of colloidal gold reagents for the surface tagging of cells has been
reported by many researchers. However, it is necessary to make the sample
conductive and the long time accepted procedure for doing this has been
by carbon coating. However, a carbon coated sample lacks the three
dimensional "appearance" of a gold coated sample, for example, thereby
making the results a challenge to properly interpret.
Gold or any other precious metal, applied by sputtering techniques, would
always result in a layer that is just too thick to all the gold signal to
pass through to the BSE detector. However, when osmium metal is deposited
with the OPC Osmium Plasma Coater, a layer
so much thinner can be applied and still achieve the desired conductivity, that
its presence does not
interfere at all with the detection of the gold tagged cells.
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Friday July 04, 2008
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