Unbiased Stereology: Three Dimensional Measurement in Microscopy

Royal Microscopical Society, MICROSCOPY HANDBOOK SERIES No. 41
C.V. Howard and M.G. Reed^© 1998, 246 pgs., illustrated, soft cover

In Unbiased Stereology, the authors present a practical guide to making unbiased 3D measurements using microscopy. Among microscopy books generally, this is one of the best. Stereology is the statistical inference of geometric parameters from spatially sampled information; it is considered unbiased when the test probes are positioned in an appropriately random manner. Now that unbiased stereology is required for nerve-cell counts in neurotoxicology by the FDA and by many journals before the acceptance of an article or study, this book is essential reading. It includes only those stereological techniques that have been tried and tested by actual application. Although these techniques are essentially mathematical - unbiased stereology is a quantitative rather than qualitative approach to microscopy - the authors do not immerse the reader in complex theories. Instead, they provide simple heuristic explanations and references to the original proof, illustrating the theory with analogies drawn from everyday experience. Exercises - provided at the end of each chapter, complete with detailed worked answers - have been developed by the authors or donated by other expert stereologists to give practical experience using the techniques. Specific topics covered include: random sampling and random geometry; the estimation of feature volume, surface, length, number and mean particle size; as well as statistics for stereologists.

SPI #	Each		In Stock
09207-AB	$ 25.00		Yes

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